124996-02-7

Basic information

• Product Name: (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone
• Synonyms: (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone
• CAS NO: 124996-02-7
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.2919
• Mol File: 124996-02-7.mol

Chemical Properties

• Boiling Point: 445.3°Cat760mmHg
• Flash Point: 189.8°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 1.52E-08mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone(124996-02-7)
• EPA Substance Registry System: (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone(124996-02-7)

Safety Data

• Hazardous Substances Data: 124996-02-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. Its role in the development of new drug treatments makes it a valuable compound in the pharmaceutical industry.
Used in Research and Development:
In the field of research and development, (E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone is used as a precursor for the synthesis of biologically active molecules. Its potential applications in creating new compounds with therapeutic properties contribute to the advancement of scientific knowledge and the development of novel treatments for various diseases.
Used in Organic Chemistry:
(E)-3,4-Dihydro-2-((4-hydroxyphenyl)methylene)-1(2H)-naphthalenone is also utilized in organic chemistry as a key intermediate for the synthesis of complex organic compounds. Its versatility in chemical reactions allows for the creation of a wide range of molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C17H14O2/c18-15-9-5-12(6-10-15)11-14-8-7-13-3-1-2-4-16(13)17(14)19/h1-6,9-11,18H,7-8H2/b14-11+

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 49629-37-0 (E)-2-(4-methoxybenzylidene)-3,4-dihydro-2H-naphthalen-1-one 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 135586-54-8 2--1-tetralone 
• 135586-56-0 2-(p-acetoxybenzylidene)-1-tetralone 
• 135586-63-9 3,3a-trans-2-acetyl-3(p-hydroxyphenyl)-2H-3,3a,4,5-tetrahydronaphtho<1,2-c>pyrazole 
• 135586-63-9 3,3a-cis-2-acetyl-3(p-hydroxyphenyl)-2H-3,3a,4,5-tetrahydronaphtho<1,2-c>pyrazole 
• 135586-57-1 2(p-carbethoxymethoxybenzylidene)-1-tetralone 
• 135586-58-2 2(p-carboxymethoxybenzylidene)-1-tetralone 
• 135586-73-1 3,3a-trans-2-acetyl-3--3,3a,4,5-tetrahydronaphtho<1,2-c>pyrazole 
• 1628798-68-4 4-(9-(4-chlorophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-7-yl)phenol 
• 1628798-73-1 4-(9-(4-bromophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-7-yl)phenol 
• 125026-06-4 <(oxyisobutyrate d'ethyle)-4' benzylidene>-2 tetralone-1 

Relevant articles and documents

Ground- and excited-state properties of some 3,4-dihydro-1-(2-p-substituted benzylidene)naphthalenones: Substituent and environmental effects

Electronic absorption and steady-state fluorescence emission of seven 3,4-dihydro-1-(2-p-substituted benzylidene)naphthalenones (1-7) show sizable solvent dependence. The charge-transfer (CT) absorption maxima of these compounds in various solvents show a

A class of 2-benzylene tetrahydronaphthalone derivatives and preparation methods and applications thereof

The present invention relates to the field of biotechnology, discloses a class of 2-benzylene tetrahydrophthalone derivatives and preparation methods and applications thereof. 2-Benzylene tetrahydronaphthalone derivative having the following structural formula, wherein R1 is selected from chlorine, bromine, iodine, alkyl, alkoxy, substituted or unsubstituted amino, alkylthio, alkyneoxy, hydroxy or hydroxymethyl group; R2, R3, R4 are hydrogen or carboxyl-containing substituents, and R2, R3, or R4 At least one of them is a carboxyl-containing substituent group. The present invention innovatively proposes a class of 2-benzylene tetrahydronaphthalone derivatives as a new skeleton of firefly luciferase inhibitors. A class of 2-benzylene tetrahydronaphthone derivatives of the present invention having a highly efficient inhibitor of nanomolar and a nanamol IC50; by competing with D- fluorescein reversibly inhibits firefly luciferase, and exhibits a high effect of firefly glowworm luciferase inhibition at the enzyme, intracellular and in vivo levels; at the same time, it is shown that it has good biocompatibility and application potential.

Tyrosinase Inhibitory Effects of Derivatives of (E)-2-(Substituted Benzylidene)-3,4-Dihydronaphthalen-1(2H)-One

Tyrosinase plays an essential role in melanin biosynthesis, and as such it has received great attention as a key target for the treatment of pigmentation disorders. In our earlier studies, we explored analogs with the β-phenyl-α,β-unsaturated carbonyl tem

Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of α,α′-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones

Abstract: α,α′-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET techniques. The analysis revealed that the present catalyst has basic sites which promote the synthesis of desired products. The main attractions of our protocol are utilization of highly abundant bio-waste-derived catalyst and good-to-excellent yield in shortest reaction time. This green protocol was further extended for structurally diverse 2-arylidene-1-tetralones by condensation of equimolar quantity of aromatic aldehydes and 1-tetralone at low temperature. The catalyst could be quantitatively recovered and reused effectively for five times. Graphic abstract: [Figure not available: see fulltext.].

Synthesis, characterization, and investigations of antimicrobial activity of 6,6-dimethyl-3-aryl-3′,4′,6,7-tetrahydro-1′H,3H-spiro[benzofuran-2,2′-naphthalene]-1′,4(5H)-dione

Chalcone-like compounds 3a–l, 2-(benzylidene)-3,4-dihydronaphthalen-1(2H)-one, were synthesized from the addition of different benzaldehyde derivatives (2a–l) to 1,2,3,4-tetrahydro-1-napthalone (1) in basic medium. Mn(OAc)3-mediated addition of

p-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: Molecular modeling and in vitro antitumor activity against hepatocellular carcinoma

In our efforts to address the rising incidence of hepatocellular carcinoma (HCC), we have made a commitment to the synthesis of novel molecules to combat Hep-G2 cells. A facile and highly efficient one-pot, multicomponent reaction has been successfully de

Solvent-free microwave enhanced synthesis of 2-arylidene-1-tetralones

A rapid and efficient method for the synthesis of 2-arylidene-1-tetralones 2 by the condensation of 1-tetralone 1 with aromatic aldehydes in the presence of p-toluenesulphonic acid (PTSA) in solvent free conditions under microwave irradiation is reported.

Synthesis of 3,3a-trans/cis-2-phenyl/acetyl-3-aryl-tetrahydroindeno/naphtho-and hexahydrobenzocycloheptapyrazoles as antiimplantation agents

Reaction of benzocycloalkanones (1-3 and 24) and araldehydes (4-6) gives the arylideno-alkanones (7-12, 25 and 26) of which 11 and 12 on alkylation and acetylation afford alkyl ethers (13, 14 and 17) and acetates (15 and 16) respectively.Condensation of a