1251537-48-0

Basic information

• Product Name: 1-BENZYL-PIPERIDINE-4-BORONIC ACID
• Synonyms: 1-BENZYL-PIPERIDINE-4-BORONIC ACID;(1-Benzylpiperidin-4-yl)boronic acid
• CAS NO: 1251537-48-0
• Molecular Formula: C₁₂H₁₈BNO₂
• Molecular Weight: 219.09
• Mol File: 1251537-48-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(1251537-48-0)
• EPA Substance Registry System: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(1251537-48-0)

Safety Data

• Hazardous Substances Data: 1251537-48-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Benzyl-piperidine-4-boronic acid is used as a reagent in organic synthesis for its ability to engage in Suzuki-Miyaura cross-coupling reactions. These reactions are crucial for the formation of carbon-carbon bonds in the synthesis of complex organic molecules, facilitating the creation of a diverse range of chemical structures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-benzyl-piperidine-4-boronic acid is utilized as a valuable intermediate. Its structural components, including the piperidine ring, are prevalent in many pharmaceuticals and bioactive compounds. This makes the compound instrumental in the development of new drugs and therapeutic agents.
Used in Drug Discovery:
1-Benzyl-piperidine-4-boronic acid is employed as a key intermediate in drug discovery due to its potential to be incorporated into various drug candidates. Its unique structure allows for the design and synthesis of novel compounds with potential therapeutic applications.
Used in Pharmaceutical Research:
In pharmaceutical research, 1-benzyl-piperidine-4-boronic acid is used as a building block for the development of new pharmaceuticals. Its versatility in chemical reactions and its presence in existing bioactive molecules make it an attractive candidate for further exploration and innovation in drug design.

Upstream product

• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 67848-71-9 4-chloro-1-benzylpiperidine 
• 6562-41-0 chloro-bis(dimethylamino)borane 
• 7732-18-5 water 

Relevant articles and documents

Process method for synthesizing N-substituted piperidine-4-boric acid

The invention relates to an organic compound synthesis method, and relates to a process method for synthesizing N-substituted piperidine-4-boric acid, which comprises the following steps of: reactingN-substituted piperidine-4-alcohol used as a raw material with thionyl chloride and organic alkali in a solvent to generate N-substituted piperidine-4-chlorine, reacting the N-substituted piperidine-4-chlorine used as a raw material with lithium metal and bis (N, N-dimethylamino) borane halide in a solvent, quenching and acidifying to obtain N-substituted piperidine-4-boric acid. The process method has the advantages of originality, low cost, safety and mild reaction conditions, avoids the dangerous reaction that other patented methods adopt expensive palladium hydroxide hydrogenation, has potential cost advantage and safety advantage, and is suitable for industrial scale-up production.

A General C(sp3)-C(sp3) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids

A general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and 1°, 2°, or 3° alkyl boronic acids is reported. The base-promoted reaction is operationally simple and exhibits a broad substrate scope to forge a variety of alkyl-alkyl bonds, including between sterically encumbered secondary and tertiary sp3-carbons. The ability of this method to simplify retrosynthetic analysis is exemplified by the improved synthesis of multiple medicinally relevant scaffolds.

INHIBITORS OF FATTY ACID AMIDE HYDROLASE

Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3/