Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5)
A new series of imidazo[2,1-b][1,3,4]thiadiazoles 5(a-g), 6(a-g), 9(a-i) and 12(a-h) were synthesized as transforming growth factor-β (TGF-β) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitors. These compounds were evaluated
Bridgehead Nitrogen Heterocycles: Facile Synthesis of Imidazo -1,3,4-Thiadiazoles Using Hypervalent Iodine
2,6 Diarylimidazo -1,3,4 thiadiazoles (3) were synthesized by reactions of either α-haloketones with 2-aminothiadiazoles (1) or directly with acetophenones in the presence of benzene.The latter method is convenient and vers
Mohan, Jag,Singh, Virender,Kataria, Sangeeta
p. 617 - 619
(2007/10/03)
Heterocyclic systems containing bridgehead nitrogen atom: Reactions of 2-aminothiadiazoles with α-haloketones and ketones in presence of NBS
Synthesis of 2,6-Diarylimidazo-1,3,4-thiadiazoles (III) have been achieved by the reaction of α-haloketones with 2-aminothiadiazoles (II) or more conveniently by treating II directly with ketones in the presence of NBS.Bromination of III furnishes
Mohan, Jag,Anjaneyulu, G. S. R.,Kiran
p. 500 - 502
(2007/10/02)
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