- Pd2(dba)3-promoted synthesis of 3-N-substituted 4-aryl-1,2,3,6-tetrahydropyridine
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A novel method for the synthesis of 3-N-substituted 4-aryl-1,2,3,6- tetrahydropyridine 3 is presented. The process is carried out by the allylic bromination of 4-aryl-1,2,3,6-tetrahydropyridines 1 with N-bromosuccinimide in propanoic acid and palladium-catalyzed cross coupling of the corresponding bromide 2 with different N-based nucleophiles.
- Chang, Meng-Yang,Lin, Chung-Han,Chen, Yeh-Long,Hsu, Ru-Ting,Chang, Ching-Yao
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experimental part
p. 4886 - 4889
(2010/10/02)
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