125218-55-5

Basic information

• Product Name: 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID
• Synonyms: 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID;3-Furancarboxylicacid,3-aminotetrahydro-(9CI);3-Aminotetrahydro-3-furoicacid;3-amino-tetrahydrofuran-3-carboxylic;3-Aminotetrahydrofuran-3-...;3-aMinotetrahydro-;3-aMinooxolane-3-carboxylic acid;3-amino-3-tetrahydrofurancarboxylic acid
• CAS NO: 125218-55-5
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.12986
• EINECS: 1533716-785-6
• Product Categories: AMINOACID
• Mol File: 125218-55-5.mol

Chemical Properties

• Boiling Point: 289 ºC
• Flash Point: 128 ºC
• Appearance: /
• Density: 1.337
• Vapor Pressure: 0.000577mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• PKA: 2.13±0.20(Predicted)
• CAS DataBase Reference: 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID(125218-55-5)
• EPA Substance Registry System: 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID(125218-55-5)

Safety Data

• Hazardous Substances Data: 125218-55-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 1181, 1989 DOI: 10.1016/S0040-4039(00)72710-9

InChI:InChI=1/C5H9NO3/c6-5(4(7)8)1-2-9-3-5/h1-3,6H2,(H,7,8)

Upstream product

• 125218-61-3 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-furan-3-carboxylic acid benzyl ester 
• 125218-57-7 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-hydroxy-butyric acid; compound with triethyl-amine 
• 869785-31-9 (+/-)-3-(tert-butoxycarbonylamino)tetrahydrofuran-1-carboxylic acid 
• 125218-60-2 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(2-methoxy-ethoxymethoxy)-butyric acid benzyl ester 
• 81866-98-0 7-oxa-1,3-diazaspiro[4.4]nonane-2,4-dione 

Downstream Products

• 1037301-08-8 rac-3-amino-tetrahydro-furan-3-carboxylic acid butyl ester 
• 1037300-95-0 rac-3-amino-tetrahydro-furan-3-carboxylic acid phenethyl ester x para-toluenesulfonic acid 
• 869785-31-9 (+/-)-3-(tert-butoxycarbonylamino)tetrahydrofuran-1-carboxylic acid 

Relevant articles and documents

NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS

The invention relates to novel substituted thiophene-2-carboxamides of general formula (I), in which A, and R1 to R8c are defined as cited in claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts, in particular the physiologically compatible salts of said compounds containing inorganic or organic acids or bases, which exhibit valuable properties.

A new series of cyclic amino acids as inhibitors of S-adenosyl L- methionine synthetase

Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3- amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (α-isoform) fractionated from E. coli transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors of the enzyme with respect to L-methionine.

PREPARATION OF HETEROCYCLIC AMINO ACIDS VIA INTRAMOLECULAR MUKAIYAMA ALDOL CONDENSATION: SYNTHESIS OF A NOVEL CYCLOLEUCINE ANALOGUE

A novel 5-endoeexon intramolecular Mukaiyama aldol condensation was employed in a simple synthesis of 3-amino-3-tetrahydrofurancarboxylic acid, an oxygenated cycloleucine analogue.