This invention describes the series of compounds based on the 3-deazaneplanocin A (DZNep) core structure designed to inhibit the function of Polycomb repressive complex 2 (PRC2) proteins.
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Page/Page column 36
(2010/04/27)
An efficient Mitsunobu coupling to adenine-derived carbocyclic nucleosides
Adenine is a poor substrate for the Mitsunobu process to carbocyclic nucleosides. However, N-6 amino bis-Boc-protected adenine is reported herein to undergo an efficient coupling under these conditions as a result of its increased solubility and the reduc
Yin, Xue-qiang,Li, Wei-kuan,Schneller, Stewart W.
p. 9187 - 9189
(2007/10/03)
4'-Modified Analogues of Aristeromycin and Neplanocin A: Synthesis and Inhibitory Activity toward S-Adenosyl-L-homocysteine Hydrolase
The carbocyclic adenosine analogues aristeromycin and neplanocin A both display significant S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitory activity and broad-spectrum antiviral effects.Since phosphorylation of the 4'-hydroxymethyl substituent has
Wolfe, Michael S.,Lee, Younha,Bartlett, William J.,Borcherding, David R.,Borchardt, Ronald T.
p. 1782 - 1791
(2007/10/02)
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