125409-63-4Relevant academic research and scientific papers
3-DEAZANEPLANOCIN DERIVATIVES
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Page/Page column 36, (2010/04/27)
This invention describes the series of compounds based on the 3-deazaneplanocin A (DZNep) core structure designed to inhibit the function of Polycomb repressive complex 2 (PRC2) proteins.
An efficient Mitsunobu coupling to adenine-derived carbocyclic nucleosides
Yin, Xue-qiang,Li, Wei-kuan,Schneller, Stewart W.
, p. 9187 - 9189 (2007/10/03)
Adenine is a poor substrate for the Mitsunobu process to carbocyclic nucleosides. However, N-6 amino bis-Boc-protected adenine is reported herein to undergo an efficient coupling under these conditions as a result of its increased solubility and the reduc
4'-Modified Analogues of Aristeromycin and Neplanocin A: Synthesis and Inhibitory Activity toward S-Adenosyl-L-homocysteine Hydrolase
Wolfe, Michael S.,Lee, Younha,Bartlett, William J.,Borcherding, David R.,Borchardt, Ronald T.
, p. 1782 - 1791 (2007/10/02)
The carbocyclic adenosine analogues aristeromycin and neplanocin A both display significant S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitory activity and broad-spectrum antiviral effects.Since phosphorylation of the 4'-hydroxymethyl substituent has
