- DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS
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The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.
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Page/Page column 18
(2011/12/13)
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- Syntheses and characterization of palladium complexes with a hemilabile "pCO" pincer ligand
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The synthesis of a new pincer ligand (tBuPCO = 2-(CH 2PtBu2)-6-(CH2OCH3)C 6H3) is reported. This ligand has been observed to coordinate in three different modes to pal
- Fulmer, Gregory R.,Kaminsky, Werner,Kemp, Richard A.,Goldberg, Karen I.
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experimental part
p. 1627 - 1636
(2011/04/25)
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- Microbial Stereodifferentiating Reduction of (+/-)4-Methyl- and (+/-)-6-Methyl-1-oxometacyclophanes and Revision of the Absolute Configuration of 4-Substituted Metacyclophanes
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Partial oxidative hydrolysis of 4-bromo-1,1,10,10-bis(trimethylenedithio)metacyclophane (7) yielded the bromo ketones 8 and 9 which were respectively converted into (+/-)-4-methyl- (3) and (+/-)-6-methyl-1-oxometacyclophanes (4).The unambiguous synthesis of (+/-)-3 from 2,5-dimethylbenzoic acid (18) assigned their structures.Incubation of (+/-)-3 with Rhodotorula rubra gave a mixture of (-)-ketone 3, (-) axial alcohol 38, and (-) equatorial alcohol 39.The observed (-) Cotton effect indicated the pS configuration of (-)-3, and transformation of (-)-3 into (+)-4-methylmetacyclophane (5) permitted the assignment of the pR configuration to (+)-5, opposite to Schloegl's proposal.This conclusion was further supported by the parallel sequence of the steps starting from (+/-)-6-methyl ketone.
- Nakazaki, Masao,Hirose, Yoshiki,Shimizu, Toru,Suzuki, Takaaki,Ishii, Akira,Makimura, Masaru
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p. 1428 - 1435
(2007/10/02)
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