- Minimizing the contribution of enterohepatic recirculation to clearance in rat for the NCINI class of inhibitors of HIV
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A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors. These molecules bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4 po
- Fader, Lee D.,Carson, Rebekah,Morin, Sébastien,Bilodeau, Fran?ois,Chabot, Catherine,Halmos, Ted,Bailey, Murray D.,Kawai, Stephen H.,Coulombe, René,Laplante, Steven,Mekhssian, Kevork,Jakalian, Araz,Garneau, Michel,Duan, Jianmin,Mason, Stephen W.,Simoneau, Bruno,Fenwick, Craig,Tsantrizos, Youla,Yoakim, Christiane
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supporting information
p. 711 - 716
(2014/07/07)
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- INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Compounds of formula I wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.
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Page/Page column 120
(2010/12/01)
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