1256250-38-0Relevant articles and documents
Minimizing the contribution of enterohepatic recirculation to clearance in rat for the NCINI class of inhibitors of HIV
Fader, Lee D.,Carson, Rebekah,Morin, Sébastien,Bilodeau, Fran?ois,Chabot, Catherine,Halmos, Ted,Bailey, Murray D.,Kawai, Stephen H.,Coulombe, René,Laplante, Steven,Mekhssian, Kevork,Jakalian, Araz,Garneau, Michel,Duan, Jianmin,Mason, Stephen W.,Simoneau, Bruno,Fenwick, Craig,Tsantrizos, Youla,Yoakim, Christiane
supporting information, p. 711 - 716 (2014/07/07)
A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors. These molecules bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4 po
