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CAS

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126-52-3

ETHINAMATE, also known as a carbamate ester, is the 1-vinylcyclohexyl ester of carbamic acid. It is a short-acting sedative-hypnotic that was formerly used to treat insomnia.

126-52-3 Suppliers

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  • 126-52-3 Structure

  • Basic information

    1. Product Name: ETHINAMATE
    2. Synonyms: 1-ETHYNYLCYCLOHEXANOL CARBAMATE;ETHINAMATE;1-Ethinylcyclohexyl carbamate;1-ethinylcyclohexylcarbamate;1-ethinylcyclohexylcarbonate;1-ethynyl-cyclohexanocarbamate;1-Ethynylcyclohexyl carbamate;1-ethynylcyclohexylcarbamate
    3. CAS NO:126-52-3
    4. Molecular Formula: C9H13NO2
    5. Molecular Weight: 167.21
    6. EINECS: 204-789-4
    7. Product Categories: N/A
    8. Mol File: 126-52-3.mol

  • Chemical Properties

    1. Melting Point: 96-98°
    2. Boiling Point: bp3 118-122°
    3. Flash Point: 131°C
    4. Appearance: /
    5. Density: 1.1222 (rough estimate)
    6. Vapor Pressure: 0.00345mmHg at 25°C
    7. Refractive Index: nD21.5 1.4441 (20% in propylene glycol)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 13.40±0.50(Predicted)
    11. CAS DataBase Reference: ETHINAMATE(CAS DataBase Reference)
    12. NIST Chemistry Reference: ETHINAMATE(126-52-3)
    13. EPA Substance Registry System: ETHINAMATE(126-52-3)

  • Safety Data

    1. Hazard Codes: T,Xn
    2. Statements: 23/24/25-22
    3. Safety Statements: 22-36/37/39-45
    4. WGK Germany:
    5. RTECS: GV9275000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 126-52-3(Hazardous Substances Data)

126-52-3 Usage

Uses

Used in Pharmaceutical Industry:
ETHINAMATE is used as a sedative-hypnotic for the treatment of insomnia. It provides short-acting relief from sleep disorders due to its rapid onset and relatively short duration of action.
Used in Sleep Aid Applications:
ETHINAMATE is used as a sleep aid for individuals experiencing difficulty falling asleep or maintaining sleep. Its short-acting nature makes it suitable for addressing acute sleep issues without causing prolonged sedation or dependency.

Originator

Valmid,Dista,US,1955

Manufacturing Process

A solution of 34 cc (0.5 mol) of liquid phosgene in 150 cc of absolute ether is reacted while cooling with a mixture of sodium chloride and ice, first with 62 grams (0.5 mol) of 1-ethinyl cyclohexanol-1 and then with 64 cc (0.5 mol) of quinoline. The precipitated quinoline chlorohydrate is filtered off and the filtrate is reacted with ammonia in ether. In this manner 45 grams of the carbamic acid ester of 1-ethinyl cyclohexanol are obtained. Yield: 53% of the theoretical yield. The ester boils at 108° to 110°C/3 mm and on recrystallization from cyclohexane, yields colorless needles melting at 94° to 96°C.

Therapeutic Function

Sedative

Safety Profile

A deadly human poison. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.

Check Digit Verification of cas no

The CAS Registry Mumber 126-52-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 126-52:
(5*1)+(4*2)+(3*6)+(2*5)+(1*2)=43
43 % 10 = 3
So 126-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)

126-52-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethinamate

1.2 Other means of identification

Product number -
Other names 1-Ethynylcyclohexyl carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126-52-3 SDS

126-52-3Upstream product

126-52-3Related news

Scientific EditionAn Investigation of the Possible Potentiation of ETHINAMATE (cas 126-52-3) Activity by Chlorpromazine*09/26/2019

Results of an attempt to determine the extent of the ability of chlorpromazine under specific circumstances to potentiate the hypnotic activity of ethinamate are presented. These results are compared with those pertaining to the extent of the ability of chlorpromazine to enhance ethinamate toxicity.detailed

ETHINAMATE (cas 126-52-3) (valmid) in dentistry09/24/2019

A double-blind study with ethinamate and a placebo was performed, with 114 patients receiving ethinamate and 98 receiving placebo. Ethinamate was judged by both operators and patients to be of definite value. The dosage of ethinamate used in the study was one tablet, 500 mg.detailed

Research ArticlesGLC Determination of ETHINAMATE (cas 126-52-3) and Its Hydroxy Derivative in Biological Fluids09/09/2019

A sensitive, specific GLC assay was developed for the determination of ethinamate in plasma and its major metabolite, trans-4-hydroxyethinamate, in urine. The assay uses a mass internal standard of dimethylethinamate. Ethinamate is extracted from alkalinized plasma with dichloromethane. Urine sa...detailed

126-52-3Relevant articles and documents

Carbonylation of propargyl carbamates with palladium(II) bisoxazoline catalysts: Efficient synthesis of 5-methoxy-3(2H)-furanones

Kusakabe, Taichi,Takahashi, Takeo,Shen, Rong,Ikeda, Ayumi,Dhage, Yogesh Daulat,Kanno, Yuichro,Inouye, Yoshio,Sasai, Hiroaki,Mochida, Tomoyuki,Kato, Keisuke

supporting information, p. 7845 - 7849 (2013/08/23)

Palladium and CO: Carbonylation of 1 with [Pd(tfa)2(±)- L1] (tfa=trifluoroacetate) affords the spirofuranone 2 with inversion of the stereochemistry at C17 in 96 % yield. C17-epi-1 also gave the same product 2 with retention of the stereochemistry at C17. Labelling studies show that 13CO was incorporated into the C5′ position of the furanone ring. The first asymmetric version of this new reaction was achieved. Copyright