1261524-75-7

Basic information

• Product Name: (3-BROMO-2-CHLOROPHENYL)METHANOL
• Synonyms: (3-BROMO-2-CHLOROPHENYL)METHANOL;3-Bromo-2-chlorobenzyl alcohol
• CAS NO: 1261524-75-7
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.47894
• EINECS: -0
• Mol File: 1261524-75-7.mol

Chemical Properties

• Boiling Point: 307.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.685±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.69±0.10(Predicted)
• CAS DataBase Reference: (3-BROMO-2-CHLOROPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMO-2-CHLOROPHENYL)METHANOL(1261524-75-7)
• EPA Substance Registry System: (3-BROMO-2-CHLOROPHENYL)METHANOL(1261524-75-7)

Safety Data

• Hazardous Substances Data: 1261524-75-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3-BROMO-2-CHLOROPHENYL)METHANOL is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications. Its reactivity allows for the creation of diverse chemical structures, which can be tailored for specific therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (3-BROMO-2-CHLOROPHENYL)METHANOL is employed as an intermediate in the production of pesticides and other agrochemicals. Its versatility in organic synthesis enables the development of effective compounds for crop protection and enhancement of agricultural productivity.
Used in Organic Synthesis Research:
(3-BROMO-2-CHLOROPHENYL)METHANOL is utilized as a building block in organic synthesis research, providing a foundation for the creation of novel organic molecules with potential applications in various fields, such as materials science, chemical engineering, and biotechnology.
Used in Chemical Production:
As a chemical compound with diverse applications, (3-BROMO-2-CHLOROPHENYL)METHANOL is used in the production of various chemicals, including those for industrial processes and specialty chemicals that serve different markets and applications.

Upstream product

• 1197050-28-4 3-bromo-2-chloro-benzaldehyde 
• 56961-27-4 3-bromo-2-chloro-benzoic acid 
• 871224-19-0 methyl 3-bromo-2-chlorobenzoate 
• 120100-15-4 methyl 3-amino-2-chlorobenzoate 
• 53553-14-3 2-chloro-3-nitrobenzoic acid methyl ester 

Downstream Products

• 1197050-28-4 3-bromo-2-chloro-benzaldehyde 
• 1044256-89-4 1-bromo-3-(bromomethyl)-2-chlorobenzene 
• 1400755-07-8 [2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol 
• 1044256-91-8 (3-bromo-2-chlorophenyl)methanamine 
• 1374574-18-1 5-bromo-4-chloro-2-benzofuran-1(3H)-one 

Relevant articles and documents

Novel biphenyl derivative as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and discloses biphenyl derivatives with PD-1/PD-L1 inhibitory activity as well as a preparation method and application of the biphenyl derivatives. The invention further discloses a composition containing the biphenyl derivative with the PD-1/PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and application of the biphenyl derivative in preparation of a PD-1/PD-L1 inhibitor. The compound can be used for treating tumors.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

PYRIDAZINONES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Benzoxadiazole compound and preparation method and medical use thereof

The invention discloses a benzoxadiazole compound and a preparation method and medical use thereof. The benzoxadiazole compound has the general structure shown in formula (I). The compound or pharmaceutically acceptable salts, tautomers, mesomers, racemates, stereoisomers, metabolites, metabolic precursors, prodrugs or solvates of the benzoxadiazole compound have an obvious inhibiting effect on PD-1/PD-L1 protein-protein interaction, so that the benzoxadiazole compound shown in the description can be applied to the preparation of an inhibitor with a PD-1/ PD-L1 inhibitory activity and the immunotherapy of tumors as an immunocheckpoint inhibitor.

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.