cas 1262410-84-3, 1-Boc-3-fluoropyrrolidine-3-Methanol | Articles data ｜lookchem

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1262410-84-3

Articles about 1262410-84-3Total 5 be found

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Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents
Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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Paragraph 0488; 0489

(2019/08/22)

Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis
A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.
Fjelbye, Kasper,Marigo, Mauro,Clausen, Rasmus Pr?torius,Juhl, Karsten
supporting information
p. 425 - 428
(2017/02/24)

Determination of the absolute configuration of (+)- and (?)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate
Racemic N-CBZ-3-fluoropyrrolidine-3-methanol (±)-1 was resolved by preparative chiral HPLC. The absolute configuration of the enantiomers of 1 was identified by vibrational circular dichroism and confirmed by chemical synthesis, which involved exchanging the CBZ protecting group of (?)-1 with Boc, followed by oxidation with RuCl3, NaIO4, activation of the resulting acid with carbonyl diimidazole and reaction with (R)-α-methylbenzylamine to give (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl) pyrrolidine-1-carboxylate 7. The latter was compared with authentic (S)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate 6 and its diastereomer 7; the configuration of diastereomer 6 was obtained by an X-ray diffraction study. This established that the enantiomer (?)-1 had an (R)-configuration.
Procopiou, Panayiotis A.,Hatley, Richard J.D.,Lynn, Sean M.,Copley, Royston C.B.,He, Yanan,Minick, Douglas J.
p. 1222 - 1230
(2016/11/23)

NOVEL COMPOUNDS
A compound of formula (I): being 4-(3-Fluoro-3-(2-(5, 6, 7, 8-tetrahydro-l, 8-naphthyridin-2-yl) ethyl) pyrrolidin-l-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.
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(2016/06/06)

NOVEL COMPOUNDS
A compound of formula (I): wherein R represents H or F, or a salt thereof.
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Page/Page column 49-50

(2016/04/20)

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Chemical Properties

Boiling Point: 292.6±25.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PKA: 14.93±0.10(Predicted)
PSA: 49.77000
LogP: 1.26570

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