1262410-84-3

Usage

Uses

Used in Organic Synthesis:
1-Boc-3-fluoropyrrolidine-3-Methanol is used as a building block for the synthesis of complex organic molecules due to its unique structure and functional groups. The Boc protecting group enhances the stability and specificity of organic reactions, making it a valuable component in the creation of various organic compounds.
Used in Pharmaceutical Research:
1-Boc-3-fluoropyrrolidine-3-Methanol is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and functional groups make it a promising candidate for the synthesis of bioactive molecules with potential therapeutic applications. The presence of the hydroxyl group allows for further derivatization and modification to fine-tune the compound's properties for specific pharmaceutical applications.
Used in Chemical Modification:
1-Boc-3-fluoropyrrolidine-3-Methanol is used as a starting material for the modification of other chemical compounds. The hydroxyl group present in the molecule offers opportunities for further derivatization, enabling the synthesis of new compounds with tailored properties for specific applications in various industries.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1057322-52-7 tert-butyl 3-fluoro-3-formylpyrrolidine-1-carboxylate 
• 59379-02-1 tert-butyl 3-formylpyrrolidine-1-carboxylate 
• 114214-69-6 tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 85310-69-6 pyrrolidin-3-ylmethanol 
• 1438852-72-2 (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents

Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.

Determination of the absolute configuration of (+)- and (?)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate

Racemic N-CBZ-3-fluoropyrrolidine-3-methanol (±)-1 was resolved by preparative chiral HPLC. The absolute configuration of the enantiomers of 1 was identified by vibrational circular dichroism and confirmed by chemical synthesis, which involved exchanging the CBZ protecting group of (?)-1 with Boc, followed by oxidation with RuCl3, NaIO4, activation of the resulting acid with carbonyl diimidazole and reaction with (R)-α-methylbenzylamine to give (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl) pyrrolidine-1-carboxylate 7. The latter was compared with authentic (S)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate 6 and its diastereomer 7; the configuration of diastereomer 6 was obtained by an X-ray diffraction study. This established that the enantiomer (?)-1 had an (R)-configuration.

NOVEL COMPOUNDS

A compound of formula (I): being 4-(3-Fluoro-3-(2-(5, 6, 7, 8-tetrahydro-l, 8-naphthyridin-2-yl) ethyl) pyrrolidin-l-yl)-3-(3-(2-methoxyethoxy) phenyl) butanoic acid, or a salt thereof.

NOVEL COMPOUNDS

A compound of formula (I): wherein R represents H or F, or a salt thereof.