126245-54-3

Basic information

• Product Name: 2-amino-4-(3-bromophenyl)-6-phenylnicotinonitrile
• Synonyms: 2-amino-4-(3-bromophenyl)-6-phenylnicotinonitrile
• CAS NO: 126245-54-3
• Molecular Formula: C₁₈H₁₂BrN₃
• Molecular Weight: 350.21198
• Mol File: 126245-54-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-4-(3-bromophenyl)-6-phenylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-(3-bromophenyl)-6-phenylnicotinonitrile(126245-54-3)
• EPA Substance Registry System: 2-amino-4-(3-bromophenyl)-6-phenylnicotinonitrile(126245-54-3)

Safety Data

• Hazardous Substances Data: 126245-54-3(Hazardous Substances Data)

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 98-86-2 acetophenone 
• 109-77-3 malononitrile 

Relevant articles and documents

Four-Component Synthesis of 2-Amino-3-Cyanopyridine Derivatives Catalyzed by Cu@imineZCMNPs as a Novel, Efficient and Simple Nanocatalyst Under Solvent-Free Conditions

Abstract: An efficient and convenient method was investigated for synthesis of 2-amino-3-cyanopyridine derivatives via a one-pot four-component reaction of various types of aldehydes, acetophenone, malononitrile, and ammonium acetate in the presence of 10

Fe3O4@TiO2@O2PO2(CH2)NHSO3H as a novel nanomagnetic catalyst: Application to the preparation of 2-amino-4,6-diphenylnicotinonitriles via anomeric-based oxidation

A new, green and reusable nanomagnetic heterogeneous catalyst, namely Fe3O4@TiO2@O2PO2(CH2)NHSO3H, was synthesized and fully characterized using suitable techniques such as infrared spectroscopy, X-ray diffraction, scanning and transmission electron microscopies, thermogravimetry, vibrating sample magnetometry and energy-dispersive X-ray spectroscopy. The applicability of the constructed heterogeneous core–shell catalyst as a promoter was successfully explored for the synthesis of 2-amino-4,6-diphenylnicotinonitrile derivatives upon the reaction of a good range of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate. The desired products were obtained with good to high yields in short reaction times under solvent-free conditions. The suggested mechanism offers an anomeric-based oxidation route to the products in the final step of the synthetic pathway.

Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3 catalyst for 2-amino-3-cyanopyridine preparation: Via an anomeric based oxidation

2-Amino-4,6-diphenylnicotinonitriles were prepared by using Fe3O4@SiO2@(CH2)3Im}C(CN)3 as a nanostructured catalyst with an ionic liquid tag under solvent free and benign conditions. Experimental evidence and theoretical studies confirmed that the final step of the synthetic pathway proceeded via an anomeric based oxidation mechanism. A good range of aromatic aldehydes were condensed with acetophenone derivatives, malononitrile and ammonium acetate to afford their corresponding products in short reaction times and good to high yields.

Synthesis of alkynyl/alkenyl-substituted pyridine derivatives via heterocyclization and Pd-mediated Sonogashira/Heck coupling process in one-pot: A new MCR strategy

A new class of 2-amino-4-(3/2-(alkynyl)/3-(alkenyl)phenyl)-6- phenylnicotinonitriles (6, 7 & 9) has been synthesized with good to excellent isolated yields by the multi-component reaction (MCR) of bromobenzaldehyde (1), malononitrile (2), acetophenone (3), NH4OAc (4) and a series of terminal alkynes (5)/alkenes (8) in the presence of pyrrolidine and Pd-catalyst in a mixture of H2O-DME (1:4 ratio) under reflux conditions in a single step. The Heck-type coupling with terminal olefins takes place stereoselectively with exclusive formation of E-isomers. This new MCR strategy opens new avenues in the development of (i) a diversity-oriented new cyanopyridine based compound library and (ii) new chemical entities other than the present reported molecules.