126474-24-6Relevant articles and documents
Stereocontrolled transformation of cyclohexene β-amino esters into syn- or anti-difunctionalized acyclic β2,3-amino acid derivatives
Cherepanova, Maria,Kiss, Loránd,Fül?p, Ferenc
, p. 2515 - 2522 (2014)
A stereocontrolled approach to functionalized acyclic β2,3- amino acid derivatives was accomplished from cis- or trans-2- aminocyclohexenecarboxylates derived from bicyclic β-lactam regioisomers. The transformations were based on oxidative ring cleavage through the ring C-C double bond of the cyclohexene β-amino esters, followed by functionalization of the dialdehyde intermediates with different phosphoranes. This stereospecific and stereocontrolled procedure was applied to the synthesis of acylic β2,3-amino acid derivatives functionalized with ester, nitrile, keto, alkyl or arylalkyl groups.
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- And Azepane-Based Fluorine-Containing β-Amino Acid Derivatives
Nonn, Melinda,Kara, Dominika,Ouchakour, Lamiaa,Forró, Eniko,Haukka, Matti,Kiss, Loránd
, p. 1163 - 1173 (2020/12/28)
Structural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.
