126503-08-0

Basic information

• Product Name: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester
• Synonyms: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester
• CAS NO: 126503-08-0
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.32602
• Mol File: 126503-08-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester(126503-08-0)
• EPA Substance Registry System: 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester(126503-08-0)

Safety Data

• Hazardous Substances Data: 126503-08-0(Hazardous Substances Data)

Usage

Molecular Structure

A complex structure consisting of a spiro ring system with a dioxa (two oxygen atoms) and an aza (one nitrogen atom) bridge, a carboxylic acid group, a methyl group at the 7th position, and a 1,1-dimethylethyl ester group.

Functional Groups

Carboxylic acid, ester, and methyl groups.

Ester Formation

The compound is formed by the reaction of the carboxylic acid group with an alcohol, specifically 1,1-dimethylethyl alcohol, resulting in an ester linkage.

Derivative

It is a derivative of 1,4-dioxaspiro[4.5]decane, with additional functional groups attached.

Applications

Likely used in chemical research and development, and may have potential applications in pharmaceuticals or materials science due to its unique structure.

Complexity

The presence of the 1,1-dimethylethyl group adds to the complexity of the compound, making it a more intricate molecule.

Stereochemistry

The stereochemistry of the molecule is not explicitly mentioned, but it is important to consider the arrangement of atoms in three-dimensional space when studying its properties and potential applications.

Solubility

The solubility of this compound is not provided, but it can be inferred that it may be soluble in organic solvents due to the presence of the ester and methyl groups.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 123387-51-9 tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 203661-73-8 (+/-)-1-benzyl-2-methylpiperidine-4-one 
• 690273-90-6 1-benzyl-2-methyl-4-(phenylamino)piperidine-4-carbonitrile 
• 71322-99-1 2-methyl-4-oxopiperidine 
• 190906-92-4 tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate 
• 184368-70-5 (2SR,6SR)-tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate 
• 146337-39-5 trans-N-Boc-2,6-dimethylpiperidin-4-ol 

Relevant articles and documents

BENZAMIDINE DERIVATIVE

Compounds of general formula (1) and pharmacologically acceptable salts thereof: ???[wherein ??????R1 represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; ??????R2 represents a hydrogen atom or a halogen atom; ??????R3 represents a hydrogen atom, an alkyl group which may be substituted, an aralkyl group, an alkylcarbonyl group which may be substituted, an alkylsulfonyl group which may be substituted or the like; ??????each of R4 and R5 represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted, a carbamoyl group or the like; ??????R6 represents a heterocycle or the like; ??????each of R7 and R8 represents a hydrogen atom, an alkyl group or the like; ??????n represents 0, 1 or 2] ???exhibit excellent activated blood coagulation factor X inhibitory activity and are useful for the prevention or treatment of blood coagulation-related diseases.

SEROTONERGIC BENZOFURANS

The present invention provides serotonergic benzofurans of Formula (I): where A, R, R, R, R, and R are as described in the specification.

α-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines

The α'-lithiations and electrophilic substitutions of selected Boc piperidines provide single or separable diastereoisomeric 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted Boc piperidines which are readily hydrolyzed to the substituted piperidines.

α-LITHIOAMINE SYNTHETIC EQUIVALENTS FROM DIPOLE-STABILIZED CARBANIONS: THE t-BOC GROUP AS AN ACTIVATOR FOR α'-LITHIATION OF CARBAMATES

The t-Boc group activates the α'-lithiation of piperidinyl and related carbamates to give lithium reagents which add to electrophiles to provide α'-elaborated carbamates.