- BENZAMIDINE DERIVATIVE
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Compounds of general formula (1) and pharmacologically acceptable salts thereof: ???[wherein ??????R1 represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; ??????R2 represents a hydrogen atom or a halogen atom; ??????R3 represents a hydrogen atom, an alkyl group which may be substituted, an aralkyl group, an alkylcarbonyl group which may be substituted, an alkylsulfonyl group which may be substituted or the like; ??????each of R4 and R5 represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted, a carbamoyl group or the like; ??????R6 represents a heterocycle or the like; ??????each of R7 and R8 represents a hydrogen atom, an alkyl group or the like; ??????n represents 0, 1 or 2] ???exhibit excellent activated blood coagulation factor X inhibitory activity and are useful for the prevention or treatment of blood coagulation-related diseases.
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- SEROTONERGIC BENZOFURANS
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The present invention provides serotonergic benzofurans of Formula (I): where A, R, R, R, R, and R are as described in the specification.
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Page/Page column 29
(2010/02/04)
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- α-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines
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The α'-lithiations and electrophilic substitutions of selected Boc piperidines provide single or separable diastereoisomeric 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted Boc piperidines which are readily hydrolyzed to the substituted piperidines.
- Beak, Peter,Lee, Won Koo
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p. 2578 - 2580
(2007/10/02)
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- α-LITHIOAMINE SYNTHETIC EQUIVALENTS FROM DIPOLE-STABILIZED CARBANIONS: THE t-BOC GROUP AS AN ACTIVATOR FOR α'-LITHIATION OF CARBAMATES
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The t-Boc group activates the α'-lithiation of piperidinyl and related carbamates to give lithium reagents which add to electrophiles to provide α'-elaborated carbamates.
- Beak, Peter,Lee, Won-Koo
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p. 1197 - 1200
(2007/10/02)
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