126527-31-9Relevant articles and documents
Ruthenium-catalysed conversion of oxime ethers into nitriles
Anand, Naveen,Owston, Nathan A.,Parker, Alexandra J.,Slatford, Paul A.,Williams, Jonathan M.J.
, p. 7761 - 7763 (2008/02/12)
The conversion of oxime ethers into nitriles has been achieved under neutral conditions using Ru(CO)(PPh3)3H2 and the bidentate ligand Xantphos as the catalyst.
Stability of mono- and bisbenzyloxime ethers of the acetylcholinesterase reactivator TMB-4
Inkmann,Holzgrabe,Hesse
, p. 764 - 774 (2007/10/03)
Mono- and bisbenzyloxime ethers of the bispyridinium derivative TMB-4 (UNO, DUG) are potent allosteric modulators of the muscarinic receptor attracting clinical interest in case of organophosphate poisoning. In order to work out the stability of these compounds oximes, different oxime ethers and potential degradation products were synthesized and UV- and NMR-spectroscopically characterized. The process of degradation of all compounds was observed under stress conditions at varying pH-values and different temperatures by means of time-dependent NMR- and UV-measurements. The pyridinium aldoxime turned out to be rather stable, whereas the oxime ether and cyano derivatives convert to the pyridone at high pH-values and high temperature. The mechanism of degradation is discussed.
Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors
Cid,Holzgrabe,Kostenis,Mohr,Trankle
, p. 1439 - 1445 (2007/10/02)
The bis(dichlorobenzyl) ether of the bispyridinium oxime TMB 4 stabilizes antagonist binding to M2-cholinoceptors which is indicative of an allosteric action. More than 10 derivatives of the lead compound were synthesized to investigate structu
O-ALKYLATION OF PYRIDINE ALDOXIMES UNDER PHASE-TRANSFER CONDITIONS
Rubina, K.,Goldberg, Yu.,Gaukhman, A.,Shymanska, M.
, p. 3129 - 3138 (2007/10/02)
Phase-transfer catalysed alkylation of (E)-pyridine aldoximes with alkyl and benzyl halides in the benzene/10percent aq.NaOH system in the presence of tetraoctylammonium bromide proceeds regiospecifically to afford the corresponding O-ethers in good yield