1637-52-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(E)-4-Pyridinecarbaldehyde oxime is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new drugs and pesticides that can address specific medical and agricultural needs.
Used in Coordination Chemistry:
As a chelating agent, (E)-4-Pyridinecarbaldehyde oxime is used in coordination chemistry to form stable complexes with metal ions. This property is crucial for various applications, such as the development of new catalysts, sensors, and materials with unique properties.
Used in Metal Surface Treatments:
(E)-4-Pyridinecarbaldehyde oxime is employed in the manufacturing of metal surface treatments, where it helps to improve the durability, corrosion resistance, and overall performance of metal surfaces. Its use in this industry contributes to the enhancement of various metal products and their applications.
Used in Metal Extraction from Ores:
In the mining industry, (E)-4-Pyridinecarbaldehyde oxime is used in the extraction of metals from ores. Its ability to form complexes with metal ions aids in the separation and purification processes, making it an essential component in the efficient recovery of valuable metals.

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 74231-54-2 pyridine-4-carbaldehyde-((E)-O-acetyl oxime ) 
• 3731-53-1 4-(aminomethyl)pyridine 

Downstream Products

• 3240-13-9 4-(acetoxyimino-methyl)-1-methyl-pyridinium; iodide 
• 479077-33-3 4-ethoxycarbonyl-5-methyl-3-pyridin-4-yl-isoxazole 
• 1309041-59-5 (E)-N-phenylcarbamoyl-4-pyridinecarbaldehyde oxime 
• 19340-18-2 1-phenacylpyridinium-4-aldoxime chloride 
• 7375-29-3 1-benzylpyridinium-4-aldoxime chloride 

Relevant academic research and scientific papers

3-methyl-4-oxa-5-azahomoadamantane as an organocatalyst for the aerobic oxidation of primary amines to oximes in water

A simple and efficient catalytic system for the aerobic oxidation of primary amines into corresponding oximes has been developed, with 3-methyl-4-oxa-5-azahomoadamantane as catalyst, acetaldoxime as co-catalyst and water as solvent. This process, which uses oxygen (O2) as an economic and green oxidant and water as a green solvent, tolerates a wide range of substrates, affording the target oximes in moderate to excellent yields. It was found that high selectivity was achieved when 3-methyl-4-oxa-5-azahomoadamantane was used, and E-type oximes were the only detected products. A possible mechanism for this catalytic process is proposed.

A novel and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to oximes

A simple and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to corresponding oximes by using toluene as the solvent is described. This practical method can use O2 as the economic and green oxidant, tolerate a wide range of substrates, which can afford the target oximes in moderate to excellent yields.

Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists

Given its role in the mediation of energy and glucose homeostasis, the G-protein-coupled bile acid receptor1 (TGR5) is considered a potential target for the treatment of type2 diabetes mellitus and other metabolic disorders. By thorough analysis of diverse structures of published TGR5 agonists, a hypothetical ligand-based pharmacophore model was built, and a new class of potent TGR5 agonists, based on the novel 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazole core, was discovered by rational design. Three distinct synthetic methods for constructing 4,5-dihydro-1,2,4-oxadiazoles and extensive structure-activity relationship studies are reported herein. Compound (R)-54n, the structure of which was determined by single-crystal X-ray diffraction and quantum chemical solid-state TDDFT-ECD calculations, showed the best potency, with an EC50 value of 1.4nM toward hTGR5. Its favorable properties invitro warrant further investigation.

Synthesis and characterization of pyridyl propargyloximes

4-Pyridiniumaldoxime and 3-pyridiniumaldoxime are synthesized by the treatment of 4- and 3-pyridinecarboxaldehydes with hydroxylamine hydrochloride, respectively. Methyl triflate salts were obtained by the treatment of methyl triflate with corresponding 4-pyridiniumaldoxime and 4-pyridinecarboxaldehyde O-propragyloxime. The reactions of 4-pyridiniumaldoxime and 3-pyridiniumaldoxime with 3-bromo-l-trimethylsilyl-l-propyne yielded the corresponding pyridinecarboxaldehyde O-propragyloximes. The structures of these products were determined by 1'H, 13C NMR data and X-ray structural analysis.

Synthetic access to new carbamate and thiocarbamate derivatives from pyridinecarbaldehyde oximes and hydroxypyridines

The synthesis of pyridine carbamate and thiocarbamate derivates is described. A series of oxime carbamate and thiocarbamate derivatives were synthesized by the addition of 2-, 3-, and 4-pyridinecarbaldehyde oximes to isocyanates and isothiocyanates. Furth

NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND USE THEREOF

The invention relates to isoxazolopyridone derivatives of a formula (I-a): wherein R1a represents an optionally-substituted heteroaryl or phenyl group, R2a represents an optionally-substituted phenyl or heteroaryl group, and R3a

EFFETS MICELLAIRES SUR LA BASICITE ET LA REACTIVITE DE NUCLEOPHILES α AROMATIQUES

The oximation of p-nitrophenylacetate by benzaldoximates in aqueous solution is catalyzed by CTAB micelles.The catalysis is more effective when the base strength of the oximate decreases; the reactivity of benzaldoximates is not dependent on their basicity.Our data may be interpreted in terms of orbital-controlled reactions, with interactions between both the n and ? occupied orbitals of the oximates and the LUMO of the acetate.