Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions
We synthesized cinnamoyl amide type chiral P,olefin ligand (S)-4. We successfully obtained separable diastereomers of 4d and demonstrated Pd-catalyzed asymmetric allylic substitution reactions of indoles using (S,aS)-4d as a chiral ligand with high enantioselectivities (up to 98% ee). This journal is
Chiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactions
We synthesized a series of phosphine-olefin-type chiral aminophosphines, and we confirmed that these each exists as two rotamers at the C(aryl)-N(amine) bond. We also investigated the ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asymmetric allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles, and we found they gave high enantio-selectivities (up to 98% ee).
Spiro indane-based phosphine-oxazolines as highly efficient P,N ligands for enantioselective Pd-catalyzed allylic alkylation of indoles and allylic etherification
A series of indane-based phosphine-oxazoline ligands with a spirocarbon stereogenic center were examined for palladium-catalyzed asymmetric allylic alkylation of indoles. Under optimized conditions, high yields (up to 98%) and enantioselectivities (up to
Qiu, Zhongxuan,Sun, Rui,Yang, Kun,Teng, Dawei
(2019/05/01)
Chiral N-1-adamantyl-N-trans-cinnamylaniline type ligands: Synthesis and application to palladium-catalyzed asymmetric allylic alkylation of indoles
Such chiral phosphine-internal olefin hybrid type ligands as N-1-adamantyl-N-cinnamylaniline derivatives 1 with C(aryl)-N(amine) bond axial chirality were synthesized and utilized for the palladium-catalyzed asymmetric allylic alkylation of indoles to aff
Palladium-catalyzed asymmetric allylic alkylation of indoles by C-N bond axially chiral phosphine ligands
Abstract The palladium-catalyzed asymmetric allylic alkylation of indoles with 1,3-diphenyl-2-propenyl acetate using P/N-type ligands such as N-aryl indole, C-N bond axially chiral aminophosphine (aS)-L4, gave the desired products 1 in good yields and wit
Highly enantioselective Pd-catalyzed allylic alkylation of indoles using sulfur-MOP ligand
The preparation of various (R)-Sulfur-MOP ligands with aryl and alkyl substituents on sulfur, and the application of these ligands to Pd-catalyzed asymmetric allylic alkylation of indoles is reported. The sulfur substituent served as an effective stereoco