126589-82-0

Basic information

• Product Name: 2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE
• Synonyms: 2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE;2-(AcetoxyMethyl)-4-broMobutyl Acetate
• CAS NO: 126589-82-0
• Molecular Formula: C₉H₁₅BrO₄
• Molecular Weight: 267.12
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 126589-82-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE(126589-82-0)
• EPA Substance Registry System: 2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE(126589-82-0)

Safety Data

• Hazardous Substances Data: 126589-82-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-BROMOETHYL)-1,3-PROPANEDIOL DIACETATE is used as an intermediate in the synthesis of antiviral drugs for the development of medications that target and treat viral infections.
Specifically, it is used in the production of:
1. Penciclovir (PCV) (P221500): This antiviral drug is primarily used to treat herpes simplex infections, including cold sores and genital herpes. It works by inhibiting viral DNA synthesis, thereby limiting the spread of the virus within the body.
2. Famciclovir (FCV) (F101125): Famciclovir is another antiviral medication that is used to treat herpes zoster (shingles) and herpes simplex infections. It is a prodrug, which means it is converted into penciclovir in the body, exerting its antiviral effects by inhibiting viral DNA synthesis.

Upstream product

• 108-24-7 acetic anhydride 
• 78386-41-1 3-acetoxymethyl tetrahydrofuran 
• 126589-88-6 1,3-diacetoxy-2-(2-hydroxyethyl)propane 
• 558-13-4 carbon tetrabromide 
• 603-35-0 triphenylphosphine 
• 124391-75-9 3-tetrahydrofuranmethanol 

Downstream Products

• 97845-60-8 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine 
• 97845-61-9 7-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine 
• 104227-87-4 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 
• 131266-15-4 7-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF 2-ACETOXYMETHYL-4 HALO-BUT-1-YL ACETATES

A process for the preparation of 2- acetoxymethyl-4-halo-but-l-yl acetates (I) in which X is chlorine or bromine, which are useful intermediates for the preparation of antiviral medicaments such as Penciclovir and Famciclovir, comprising the opening of 3-hydroxymethyl-tetrahydrofuran (V) in the presence of an acylating agent and a Lewis acid selected from magnesium bromide and samarium triiodide.

Derivatives of purine, process for their preparation and a pharmaceutical preparation

Antivirally active compounds of formula (I), wherein R1 is hydrogen, hydroxy, mercapto or amino; R2 is hydrogen, hydroxy, fluoro, chloro or amino; R3 and R4 are independently selected from (II), (III), amino, hydroxy or an ether or ester residue thereof, or R3 together with R4 is (IV), wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R2 is amino and R3 and R4 are hydroxy R1 is not hydroxy and in addition, when n=1, R1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatments of virus infections as well as use of compounds of formula (I) without the proviso for the manufacture of a medicament for treatment of AIDS. STR1