126799-54-0Relevant articles and documents
POTENTIAL ANTIDEPRESSANTS: 4-(THIOARYLOXY)PIPERIDINES
Sindelar, Karel,Hrubantova, Marta,Svatek, Emil,Matousova, Oluse,Metysova, Jirina,et.al.
, p. 2240 - 2247 (2007/10/02)
Nucleophilic substitution reactions of a series of thio-substituted fluoroarenes with 1-methyl-4-piperidinol, 1-benzyl-4-piperidinol, and 1-methyl-4-phenyl-4-piperidinol in the presence sodium hydride in dimethylformamide gave the title compounds V-XI and XIII.The salts of these bases were pharmacologically tested and salts of compounds V, XI, and XIII showed in behavioural tests properties which are indicative of antidepressant activity.