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106-52-5

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106-52-5 Usage

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Different sources of media describe the Uses of 106-52-5 differently. You can refer to the following data:
1. Reactant for:? ;Optimization of Novobiocin scaffold to product antitumor agents1? ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:? ;CaMKII inhibitors3? ;VEGFR and FGFR kinase inhibitors4? ;Phosphoinositide-3-kinase inhibitors5? ;Protein lysine methyltransferase G9a inhibitors6
2. 4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 106-52-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 106-52:
(5*1)+(4*0)+(3*6)+(2*5)+(1*2)=35
35 % 10 = 5
So 106-52-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO.ClH/c1-7-4-2-6(8)3-5-7;/h6,8H,2-5H2,1H3;1H

106-52-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L06415)  4-Hydroxy-1-methylpiperidine, 98%   

  • 106-52-5

  • 100g

  • 308.0CNY

  • Detail
  • Alfa Aesar

  • (L06415)  4-Hydroxy-1-methylpiperidine, 98%   

  • 106-52-5

  • 500g

  • 1231.0CNY

  • Detail
  • Aldrich

  • (H42206)  N-Methyl-4-piperidinol  98%

  • 106-52-5

  • H42206-100G

  • 526.50CNY

  • Detail

106-52-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Methyl-4-piperidinol

1.2 Other means of identification

Product number -
Other names N-Methyl-4-hydroxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106-52-5 SDS

106-52-5Relevant articles and documents

Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura

Boswell, Henry D.,Draì?ger, Birgit,McLauchlan, W. Russell,Portsteffen, Andreas,Robins, David J.,Robins, Richard J.,Walton, Nicholas J.

, p. 871 - 878 (1999)

The enzymes N-methylputrescine oxidase (MPO), the tropine-forming tropinone reductase (TRI), the pseudotropine-forming tropinone reductase (TRII), the tropine:acyl-CoA transferase (TAT) and the pseudotropine:acyl-CoA transferase (PAT) extracted from transformed root cultures of Datura stramonium and a Brugmansia candida x aurea hybrid were tested for their ability to accept a range of alternative substrates. MPO activity was tested with N-alkylputrescines and N-alkylcadaverines as substrates. TRI and TRII reduction was tested against a series of N-alkylnortropinones, N- alkylnorpelletierines and structurally related ketones as substrates. TAT and PAT esterification tests used a series of N-substituted tropines, pseudotropines, pelletierinols and pseudopelletierinols as substrates to assess the formation of their respective acetyl and tigloyl esters. The results generally show that these enzymes will accept alien substrates to varying degrees. Such studies may shed some light on the overall topology of the active sites of the enzymes concerned.

Hydrogenation of hindered ketones catalyzed by a silica-supported compact phosphine-Rh system

Kawamorita, Soichiro,Hamasaka, Go,Ohmiya, Hirohisa,Hara, Kenji,Fukuoka, Atsushi,Sawamura, Masaya

, p. 4697 - 4700 (2008)

(Chemical Equation Presented) A heterogeneous mono(phosphine)-Rh catalyst system silica-SMAP-Rh(OMe)(cod), where silica-SMAP stands for a caged, compact trialkylphosphine (SMAP) supported on silica gel, showed broad applicability toward the hydrogenation of hindered ketones. Doubly α-branched ketones such as diisopropyl ketone was hydrogenated under nearly atmospheric conditions. Di-tert-butyl ketone could be hydrogenated under more forcing conditions.

Electrochemical Reductive N-Methylation with CO2Enabled by a Molecular Catalyst

Rooney, Conor L.,Wu, Yueshen,Tao, Zixu,Wang, Hailiang

supporting information, p. 19983 - 19991 (2021/12/01)

The development of benign methylation reactions utilizing CO2 as a one-carbon building block would enable a more sustainable chemical industry. Electrochemical CO2 reduction has been extensively studied, but its application for reductive methylation reactions remains out of the scope of current electrocatalysis. Here, we report the first electrochemical reductive N-methylation reaction with CO2 and demonstrate its compatibility with amines, hydroxylamines, and hydrazine. Catalyzed by cobalt phthalocyanine molecules supported on carbon nanotubes, the N-methylation reaction proceeds in aqueous media via the chemical condensation of an electrophilic carbon intermediate, proposed to be adsorbed or near-electrode formaldehyde formed from the four-electron reduction of CO2, with nucleophilic nitrogenous reactants and subsequent reduction. By comparing various amines, we discover that the nucleophilicity of the amine reactant is a descriptor for the C-N coupling efficacy. We extend the scope of the reaction to be compatible with cheap and abundant nitro-compounds by developing a cascade reduction process in which CO2 and nitro-compounds are reduced concurrently to yield N-methylamines with high monomethylation selectivity via the overall transfer of 12 electrons and 12 protons.

Bilobalide B derivative and application of bilobalide B derivative in medicine

-

Paragraph 0253; 0254; 0255, (2016/10/09)

The invention relates to a new bilobalide B derivative, hydrate, solvate or pharmacy-acceptable salt of the bilobalide B derivative, and a medicine composition with the derivative, and further relates to application of the compound or the medicine composition in preparation of medicine. The medicine is used for preventing, processing, treating or relieving cardiovascular and cerebrovascular diseases of patients. The invention further relates to a preparation method of the bilobalide B derivative.

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