A catalytic route to ampakines and their derivatives
A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances.
Mulzer, Michael,Coates, Geoffrey W.
supporting information; experimental part
p. 1426 - 1428
(2011/05/04)
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