- Novel applications of Raney nickel/isopropanol: Efficient system for the reduction of organic compounds
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Catalytic hydrogenation of various organic substrates with Raney nickle in isopropanol proceeds under mild conditions of temperature and pressure. Comparison with other catalysts systems evidenced the superiority of Raney nickel/isopropanol.
- Regla, Ignacio,Reyes, Adelfo,Koerber, Claudia,Demare, Patricia,Estrada, Osvaldo,Juaristi, Eusebio
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Read Online
- Method for preparing gamma-aminopropanol through one-step catalytic hydrogenation and application of gamma-aminopropanol
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The invention relates to a method for preparing gamma-aminopropanol through one-step catalytic hydrogenation, which comprises the following step: in the presence of a metal catalyst, beta-alanine and hydrogen are subjected to hydrogenation reaction in a reaction solvent to obtain gamma-aminopropanol. The method has the advantages that the yield is high, the purity of the prepared gamma-aminopropanol is high, the operation is simple and convenient, the raw materials are cheap and easy to obtain, the method is safe and controllable, the method is green and environment-friendly, the cost is better, the method is suitable for industrial production and the like, and the quality, the yield, the effectiveness and the safety of the product prepared from the gamma-aminopropanol are remarkably improved.
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Paragraph 0011-0018
(2021/07/17)
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- Preparation method of 3-aminopropanol
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The invention relates to a preparation method of 3-aminopropanol, wherein the preparation method comprises the following steps: (1) carrying out a reaction on acrylonitrile with benzyl alcohol under the catalysis of a base catalyst, and separating the obtained reaction solution to obtain 3-benzyloxypropionitrile; and (2) in a liquid-phase reaction system in the presence of a hydrogenation catalyst, carrying out a hydrogenation reaction on the 3-benzyloxypropionitrile, separating the obtained reaction liquid to obtain 3-aminopropanol, and recycling the obtained by-product toluene as an extractant in the step (1).
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Paragraph 0064; 0066
(2020/05/05)
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- Catalyst for producing 3-aminopropanol by hydrogenating 3-hydroxypropionitrile and preparation method thereof
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The invention discloses a catalyst for producing 3-aminopropanol by hydrogenating 3-hydroxypropionitrile. The catalyst is characterized in that the catalyst comprises an active component and a carrier, wherein the active component comprises active metal elements; the active metal elements comprise M and Re; M is selected from at least one of Ni, Co and Cu; M accounts for 5.0-50.0% of the weight ofthe catalyst; Re accounts for 0.1-15.0% of the weight of the catalyst; and the carrier is selected from at least one of inorganic porous materials. The catalyst has high catalytic activity and selectivity.
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Paragraph 0110; 0111; 0116-0118; 0126
(2020/06/09)
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- Preparation method of 3-aminopropanol
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The invention provides a preparation method of 3-aminopropanol, which is high in conversion rate. The invention adopts the following technical scheme: adding 3-hydroxypropionitrile into a reactor witha nickel catalyst and silver nitrate, and then adding an amine reagent under nitrogen; then introducing hydrogen into the reactor, stirring for reducing reaction, and performing precipitation and distillation to prepare the 3-aminopropanol. The raw materials are high in utilization rate; the separation process is simple and clear; the energy consumption is low; the production cost of a product islow; and the solvent and the catalyst can be recycled for use.
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Paragraph 0020-0089
(2019/03/28)
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- Organocatalytic Decarboxylation of Amino Acids as a Route to Bio-based Amines and Amides
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Amino acids obtained by fermentation or recovered from protein waste hydrolysates represent an excellent renewable resource for the production of bio-based chemicals. In an attempt to recycle both carbon and nitrogen, we report here on a chemocatalytic, metal-free approach for decarboxylation of amino acids, thereby providing a direct access to primary amines. In the presence of a carbonyl compound the amino acid is temporarily trapped into a Schiff base, from which the elimination of CO2 may proceed more easily. After evaluating different types of aldehydes and ketones on their activity at low catalyst loadings (≤5 mol%), isophorone was identified as powerful organocatalyst under mild conditions. After optimisation many amino acids with a neutral side chain were converted in 28–99 % yield in 2-propanol at 150 °C. When the reaction is performed in DMF, the amine is susceptible to N-formylation. This consecutive reaction is catalysed by the acidity of the amino acid reactant itself. In this way, many amino acids were efficiently transformed to the corresponding formamides in a one-pot catalytic system.
- Claes, Laurens,Janssen, Michiel,De Vos, Dirk E.
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p. 4297 - 4306
(2019/08/26)
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- Oxidative Deprotection of p-Methoxybenzyl Ethers via Metal-Free Photoredox Catalysis
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An efficient and greener deprotection method for p-methoxybenzyl (PMB) ethers using a metal-free visible light photoredox catalyst and air and ammonium persulfate as the terminal oxidants is presented. Various functional groups and protecting groups were tolerated in the developed method to achieve good to excellent yields in short reaction times. Significantly, the developed method was compatible with PMB ethers derived from primary, secondary, and tertiary alcohols and a gram-scale reaction. Mechanistic studies support a proposed reaction mechanism that involves single electron oxidation of the PMB ether.
- Ahn, Deok Kyun,Kang, Young Woo,Woo, Sang Kook
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p. 3612 - 3623
(2019/03/11)
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- METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH
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A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.
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- The invention relates to a propylene glycol and liquid ammonia as raw materials for preparing propylene diamine method and apparatus thereof
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The invention relates to a method for preparing propane diamine by taking propylene glycol and liquid ammonia as raw materials. Propylene glycol and liquid ammonia are mixed in a certain ratio and are pumped into a reactor by virtue of a pump, and reaction is carried out in presence of a catalyst and hydrogen. The method for preparing the propane diamine by taking the propylene glycol and liquid ammonia as the raw materials has the advantages that a novel catalyst is adopted, catalytic performance is excellent, and long-time operation can be easily carried out; propylene glycol is subjected to hydroamination for producing a propane diamine product at lower reaction pressure, and reaction conditions are adjusted and changed, so that composition of the product can be flexibly adjusted and changed, selectivity of a target product is improved, a reaction process is simple, one-time investment of a production unit and production cost are reduced, a reaction product and a catalyst can be simply separated, and large-scale continuous industrial production can be easily realized.
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Paragraph 0080-0081; 0090
(2017/08/31)
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- Insight into the mechanism of hydrogenation of amino acids to amino alcohols catalyzed by a heterogeneous MoOx-modified Rh catalyst
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Hydrogenation of amino acids to amino alcohols is a promising utilization of natural amino acids. We found that MoOx-modified Rh/SiO2 (Rh-MoOx/SiO2) is an efficient heterogeneous catalyst for the reaction at low temperature (323 K) and the addition of a small amount of MoOx drastically increases the activity and selectivity. Here, we report the catalytic potential of Rh-MoOx/SiO2 and the results of kinetic and spectroscopic studies to elucidate the reaction mechanism of Rh-MoOx/SiO2 catalyzed hydrogenation of amino acids to amino alcohols. Rh-MoOx/SiO2 is superior to previously reported catalysts in terms of activity and substrate scope. This reaction proceeds by direct formation of an aldehyde intermediate from the carboxylic acid moiety, which is different from the reported reaction mechanism. This mechanism can be attributed to the reactive hydride species and substrate adsorption caused by MoOx modification of Rh metal, which results in high activity, selectivity, and enantioselectivity.
- Tamura, Masazumi,Tamura, Riku,Takeda, Yasuyuki,Nakagawa, Yoshinao,Tomishige, Keiichi
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p. 3097 - 3107
(2015/02/05)
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- HIV INTEGRASE INHIBITORS
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The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
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- · Uniform catalyst by using alcohol aminosilicone di-, tri-and a method of manufacturing a polyphenylenepolyamine
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The invention relates to a method for producing primary amines, which contain at least one functional group of the formula (-CH2-NH2) and at least one further primary amino group, by the alcohol amination of reactants, which contain at least one functional group of the formula (-CH2-OH) and at least one further functional group (-X), wherein (-X) is selected from hydroxyl groups and primary amino groups, using ammonia with removal of water, wherein the reaction is carried out in a homogeneously catalyzed manner in the presence of at least one complex catalyst containing at least one element selected from groups 8, 9 and 10 of the periodic table and at least one donor ligand.
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Paragraph 0099; 0113
(2016/10/09)
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- Catalytic hydrogenation of amino acids to amino alcohols with complete retention of configuration
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Rh-MoOx/SiO2 is an effective heterogeneous catalyst for selective hydrogenation of amino acids to amino alcohols in a water solvent. MoOx modification of Rh drastically enhanced the activity and improved the selectivity and ee. Various amino alcohols were obtained in high yields (90-94%) with complete retention of configuration. This journal is the Partner Organisations 2014.
- Tamura, Masazumi,Tamura, Riku,Takeda, Yasuyuki,Nakagawa, Yoshinao,Tomishige, Keiichi
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p. 6656 - 6659
(2014/06/10)
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- PROCESS FOR PREPARING AND PURIFYING 3-AMINOPROPANOL
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The present invention relates to a process for purifying a reaction output which comprises 3-aminopropanol and is obtained in the reaction of ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises distilling the reaction output comprising 3-aminopropanol in two or more stages, the ammonia content of the reaction output comprising 3-aminopropanol before introduction into the first distillation stage being 1% by weight or less and the temperature in the distillation stages being not more than 135° C. The invention further relates to a process for preparing 3-aminopropanol by reacting ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises performing the purification of the reaction output comprising 3-aminopropanol in accordance with the invention. The present invention further provides a process for preparing 3-aminopropanol derivatives, especially panthenol, acambrosate, mefenorex, domperidon, ifosamid or urapidil, from 3-amino-propanol prepared in accordance with the invention.
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Page/Page column 9
(2012/06/18)
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- PROCESS FOR PREPARING DI-, TRI- AND POLYAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
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Process for preparing primary amines which have at least one functional group of the formula (—CH2—NH2) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH2—OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.
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Page/Page column 12; 16
(2012/09/22)
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- Pyrithione biocides enhanced by zinc metal ions and organic amines
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The present invention is directed to a stable, soluble, antimicrobial composition concentrate comprising pyrithione or a pyrithione complex in an amount of from about 0.5% to about 30 weight percent, a zinc source in an amount of from about 0.1% to about 10%, and an organic amine component in an amount of from about 30% to about 80%, said percents being based upon the total weight of the composition concentrate. The invention is also directed to methods of controlling the growth of free-living microorganisms or biofilms using the antimicrobial composition of the invention, and products made using the antimicrobial composition of the invention.
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- Pyrazolopyrimidines as therapeutic agents
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The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.
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- Process for producing 3-hydroxypropionitrile
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A process for the production of 3-hydroxypropionitrile is provided. This process includes (a) reacting acrylonitrile with water at a defined molar ratio in the presence of a weak base under specific temperature and pressure conditions until a conversion in the range of about 40% to about 80% has been achieved; (b) after cooling the mixture obtained in (a), separating off its aqueous phase; (c) distilling off the acrylonitrile from the organic phase remaining after (b); (d) subjecting the mixture obtained in (c) to pyrolysis at specific temperature and pressure conditions in the presence of a basic catalyst to obtain a mixture consisting mainly of 3-hydroxypropionitrile and acrylonitrile; and (e) isolating the desired 3-hydroxypropionitrile by fractional distillation from the mixture obtained in (d). Such a process in which the basic aqueous phase and the acrylonitrile that has been distilled off are recycled represents a preferred embodiment.
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- Solvolysis of 2-amino-2-thiazoline derivatives by aliphatic amino alcohols
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The opening of the thiazoline ring upon the action of amino alcohols was studied. The effects of the reagent ratio and structures of the heterocycles and amino alcohols on aminolysis were investigated. A new method was developed for the preparative synthesis of a series of N′-(hydroxyalkyl)-2-guanidinoalkanethiols.
- Mandrugin,Fedoseev,Dubovaya,Rodyunin,Semenko
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p. 1382 - 1388
(2007/10/03)
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- Pyrazolopyrimidines as therapeutic agents
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The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R2, and R3 are defined as described herein.
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- Cyclohexapeptidyl bisamine compounds
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Certain bisamine compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
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- Cobalt-catalyzed amination of 1,3-propanediol: Effects of catalyst promotion and use of supercritical ammonia as solvent and reactant
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The catalytic synthesis of 1,3-diaminopropane from 1,3-propanediol and ammonia was studied in a continuous fixed-bed reactor in the pressure range 50 to 150 bar. The unsupported Co-based catalysts applied were characterized by N2 physisorption, XRD, XPS, TPR, and ammonia adsorption using pulse thermal analysis and DRIFT spectroscopy. The latter investigations revealed that the best catalyst, 95 wt% Co-5 wt% Fe, contained only very weak acidic sites, unable to chemisorb ammonia. The absence of strong acidic and basic sites was crucial to suppress the various acid/base-catalyzed side reactions (retro-aldol reaction, hydrogenolysis, alkylation, disproportionation, dimerization, oligomerization). Other important requirements for improved diaminopropane formation were the use of excess ammonia (molar ratio NH3/diol > 20) and the presence of the metastable β-Co phase. A small amount of Fe additive could efficiently hinder the transformation of this phase into the thermodynamically stable α-Co phase and thus prevent catalyst deactivation up to 10 days on stream. Application of supercritical ammonia almost doubled the selectivity to amino alcohol and diamine. The selectivity enhancement in the near-critical region is attributed to elimination of the interphase mass transport limitations and to the resulting higher surface ammonia concentration.
- Fischer,Maciejewski,Buergi,Mallat,Baiker
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p. 373 - 383
(2007/10/03)
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- Continuous amination of propanediols in supercritical ammonia
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Enhancements in selectivity by a factor of 4 to 18 were observed in the near critical regions of ammonia during the Co- and Ni-catalyzed synthesis of 1,3-diamino-propanes. These results are attributed to the higher concentration of ammonia at the surface of the catalyst, which favors the amination and suppresses degredation reactions.
- Fischer, Achim,Mallat, Tamas,Baiker, Alfons
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p. 351 - 354
(2007/10/03)
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- Pharmacologically active pyridine derivatives and processes for the preparation thereof
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N-phenyl-2-pyrimidineamine derivatives of formula I STR1 wherein the substituents are as defined in claim 1 and the derivatives of formula I can be used, for example, in the treatment of tumour diseases.
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- Antineoplastic heteronapthoquinones
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This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.
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- Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
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There are disclosed novel semi-synthetic lipopeptides of the formula (Seq. ID Nos. 1-6) STR1 wherein the substituents are defined herein, which show utility as antifungal and anti-Pneumocystis agents. Pharmaceutical compositions containing said compounds are also disclosed.
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- Kinetic study of the reaction between iodide and N-chloramines
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We carried out a kinetic study of the reaction between iodide ion and various primary N-chloramines and found it to be first-order in the latter.Experiments also showed the rate constant for the reaction to be directly proportional to the iodide and hydrogen ion concentrations.The influence of the concentration reveals the presence of general acid catalysis processes.
- Antelo, J. M.,Arce, F.,Campos, J.,Parajo, M.
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p. 391 - 396
(2007/10/03)
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- N-t-butoxycarbonyl protection of primary and secondary amines in the hydroboration reaction: Synthesis of amino alcohols
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The use of the BOC group as a protecting group in the hydroboration of aminoalkenes is described. The isolated yields of amino alcohols via the hydroboration-oxidation sequence are excellent.
- Kabalka,Li,Pace
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p. 2135 - 2143
(2007/10/02)
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- Pyridazinones having cardiotonic and beta blocking activities
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Pyridazinones of the following formula (I): STR1 where R1 -R4 are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).
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- PARTICIPATION OF A NEIGHBORING AMIDE GROUP IN THE HYDROLYTIC C-OAr CLEAVAGE OF N-(ω-PHENOXYALKYL) AMIDES. PART III. N-3-PHENOXYPROPYLALKANEAMIDE
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The hydrolysis of N-3-phenoxypropyl-acetamide and -propionamide was investigated in water-dioxane (3:2) solutions of HCl in the concentration range 3.1-5.2 mol/dm3 at temperatures 75-95 deg C.Two parallel reactions were found: a simple hydrolysis of amide to N-3-phenoxypropylamine and hydrolysis with simultaneous cleavage of PhO-Calkyl bond.Rate constants of these reactions were determined.A mechanism comprising a six-membered cyclic intermediate was proposed for the hydrolysis accompanied by the cleavage of etheric bond.
- Dobrzeniecka, R.
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p. 997 - 1001
(2007/10/02)
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- Diazepine antiallergy agents
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Platelet activating factor antagonists of formula (I), (II) or (III): STR1 where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole, X is O, S or NH Y is 1,4 phenylene or a group of formula STR2 R1 is H or optionally substituted C1 -C4 alkyl, R2 and R3 are H or C1 -C4 alkyl, B is an optionally fused 5- or 6-membered ring containing nitrogen atoms, Het is an optionally substituted 5-membered heterocyclic ring containing nitrogen or a pyridine ring, the ring optionally being fused to benzene or nitrogen-containing heterocyclic ring.
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- NUCLEOPHILIC CLEAVAGE AND FORMATION OF SATURATED HETEROCYCLES. XII. REACTIVITY OF SMALL HETEROCYCLES TOWARD AMINOLYSIS AND HYDROLYSIS
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The cleavage of four-membered saturated heterocycles proceeds via a more product-like transition state than that of three-membered rings.General acid catalysis is characteristic of oxygen heterocycles, but in the case of nitrogen heterocycles catalysis is specific.The reactivity of amines in the cleavage of azetidines is linearly dependent on their pKa values, primary and secondary amines comprising separate reaction series.
- Bobylev, V. A.,Veselkov, N. Yu.,Dalin, A. R.,Sharikov, F. Yu.
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p. 1700 - 1713
(2007/10/02)
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- Process for delaying the formation and/or reducing the agglomeration tendency of hydrates
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The invention concerns a process for delaying the formation and/or reducing the agglomeration tendency of hydrates in conditions under which a hydrate may be formed, these hydrates being formed from water and gas. The process according to the invention wherein, in particular, an additive comprising at least one compound from the group of hydroxycarbylamides of substituted carboxylic acids is used. Application of the process according to the invention to processes using gases and water, which form hydrates between them, in particular in the petroleum or gas industry.
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- A systematic entropy relationship for the general-base catalysis of the deprotonation of a carbon acid. A quantitative probe of transition-state solvation
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The general-base-catalyzed deprotonation of a carbon acid, the l-methyl-4-(phenylacetyl)pyridinium cation (pKa = 9.02 at 25 °C), has been investigated for 32 general-base catalysts (25 amines and seven phenoxide ions) in aqueous solution. Amines give a generally scattered Bronsted plot; ring-substituted benzylamines have ?= 0.52, and ring-substituted phenoxides have ?= 0.60, with the phenoxides being more reactive than amines of similar basicity. The temperature dependences of the general-base-catalyzed deprotonation of this carbon acid have been measured over the range 15-45 °C for 12 base catalysts (eight primary, secondary, and tertiary amines; 4-(dimethylamino)pyridine; two phenoxide ions; hydroxide ion). The entropies of activation for these deprotonations show a clean curvilinear dependence upon the entropies of protonation of these base species, with the hydroxide ion being the only significant deviant from this relationship. This observation quantitatively establishes the importance of solvation effects as the major source of deviations that are commonly observed in Bronsted relationships for general-base-catalyzed processes.
- Bunting, John W.,Stefanidis, Dimitrios
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p. 779 - 786
(2007/10/02)
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- Triazinyl reactive dyestuffs in which triazinyl group is further substituted with a beta-chloroethylsulfonyl- or vinylsulfonylbutyrylamino moiety
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Reactive dyes of the formula STR1 in which D is the radical of an organic dye of the monoazo, polyazo, metal complex azo, anthraquinone, phthalocyanine, formazan, azomethine, dioxazine, phenazine, stilbene, triphenylmethane, xanthene, thioxanthrone, nitroaryl, naphthoquinone, pyrenequinone or perylenetetracarbimide series, R is hydrogen or substituted or unsubstituted C1-4 -alkyl, X is a substituent which is detachable as an anion, B is a radical of the formula STR2 R1 and R2, independently of each other, are hydrogen or substituted or unsubstituted C1-4 -alkyl or phenyl, A is a substituted or unsubstituted aliphatic or aromatic bridge member, Y is a --CO--Z or --SO2 --Z radical, Z is an aliphatic, aromatic or heterocyclic reactive radical, and n is 1 or 2, are suitable for dyeing or printing cellulose-containing and nitrogen-containing materials and in high dyeing yield produce dyeings and prints having good fastness properties.
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- DEBENZYLATION OF N-BENZYLAMINO DERIVATIVES BY CATALYTIC TRANSFER HYDROGENATION WITH AMMONIUM FORMATE
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A method for deprotection of several N-benzyl derivatives of amines to the corresponding amino derivatives with ammonium formate and 10percent Pd-C is reported.
- Ram, Siya,Spicer, Leonard D.
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p. 415 - 418
(2007/10/02)
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- PROTECTION OF PRIMARY AND SECONDARY AMINES IN THE HYDROBORATION REACTION
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Trimethylsilyl groups are efficient to protect the N-H bonds of olefinic amines in the hydroboration reaction with BMS; deprotection is easily run with methanol and affords aminoorganoboranes which can be used without any oxydation.
- Dicko, A.,Montury, M.,Baboulene, M.
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p. 6041 - 6044
(2007/10/02)
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- Regiospecific Opening of Oxetanes with Trimethylsilyl Cyanide - Zinc Iodide. A General Approach to γ-Amino Alcohols.
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Trimethylsilyl ethers of γ-hydroxy isonitriles were formed regiospecifically in the opening of oxetanes with trimethylsilyl cyanide - zinc iodide.Deprotection and hydrolysis of the initially formed ring cleavage products gave γ-amino alcohols.
- Gassman, Paul G.,Haberman, Leonard M.
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p. 4971 - 4974
(2007/10/02)
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- Oxidation reaction of aliphatic amines and aminoalcohols in aqueous solution induced by argon arc plasma
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Argon arc plasma induced a powerful and stepwise oxidation reaction including conversion of methyl group to carboxyl group, oxidative cleavage of carbon-carbon bond, and oxidative deamination. Main active species were considered to be hydroxyl radicals by decomposition of water molecules.
- Takasaki, Michiaki,Harada, Kaoru
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p. 4463 - 4473
(2007/10/02)
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- FLAME-INDUCED OXIDATION OF ALIPHATIC AMINES IN AN AQUEOUS SOLUTION
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When a town gas-, a hydrogen-, and an ethylene-oxigen flame were blown against the surface of aqueous solution of aliphatic amines, the amines were effectively oxidized to afford amino acids.
- Nomoto, Shinya,Takasaki, Michiaki,Sakata, Naoko,Harada, Kaoru
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p. 3357 - 3360
(2007/10/02)
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- FORMATION OF AMINO ACIDS FROM ALIPHATIC AMINES BY CONTACT GLOW DISCHARGE ELECTROLYSIS
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Oxidation of aliphatic amines in an aqueous solution by contact glow discharge electrolysis resulted in the formation of several amino acids, which was explained by the oxidative action of hydroxyl radical generated by the electric discharge process to the aqueous solution.
- Harada, Kaoru,Nomoto, Masayo M.,Gunji, Hiromi
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p. 769 - 772
(2007/10/02)
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- Composition for preventing lactation or pregnancy in mammals and the method for using the same
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α-D-6-methylergolinyl-8-acetamides of the formula: SPC1 Are readily prepared from α-D-6-methylergolinyl-8-acetic acid azide hydrochloride and amines of the formula R1 -NH-R2 and may be converted to their salts with inorganic and organic acids by neutralization. In these formulas, R1 may be hydrogen or lower alkyl, R2 may be hydrogen, lower alkyl, cycloalkyl having 5 or 6 carbon atoms, hydroxyalkyl having 3 or 4 carbon atoms, or lower alkoxycarbonylmethyl or R1 and R2 jointly may be divalent alkylene having 4 or 5 C atoms. The salts of most of these bases with physiologically tolerated acids are nontoxic in doses which suppress lactatical and prevent pregnancy in rats when applied orally after copulation. The others, equally non-toxic, extend the effective period of thiopental.
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