126961-71-5

Basic information

• Product Name: 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE
• Synonyms: 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE;1-(2-BroMophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
• CAS NO: 126961-71-5
• Molecular Formula: C₁₀H₈BrN₃O
• Molecular Weight: 266.09
• Mol File: 126961-71-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(126961-71-5)
• EPA Substance Registry System: 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE(126961-71-5)

Safety Data

• Hazardous Substances Data: 126961-71-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure contributes to the development of new drugs targeting different health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is utilized as an intermediate in the creation of compounds that serve as pesticides or fungicides, helping to protect crops and enhance agricultural productivity.
Used as Antifungal and Antibacterial Agent:
Due to its reported antifungal and antibacterial properties, 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is used in the development of treatments and preventive measures against fungal and bacterial infections, particularly in the medical and veterinary fields.
Used in DNA Topoisomerase II Inhibition Research:
As a potential inhibitor of human DNA topoisomerase II, 1-(2-BROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is employed in research aimed at understanding its effects on DNA replication and transcription. This could lead to the development of novel therapeutic strategies for diseases associated with DNA processing.

Upstream product

• 49851-55-0 2,2'-dibromoacetophenone 
• 2142-69-0 2-bromophenyl methyl ketone 
• 288-88-0 1,2,4-Triazole 
• 126961-69-1 4-Amino-1-[2-(2-bromo-phenyl)-2-oxo-ethyl]-4H-[1,2,4]triazol-1-ium; bromide 

Downstream Products

• 936105-09-8 4-(2-bromo-phenyl)-5-[1,2,4]triazol-1-yl-thiazol-2-ylamine 

Relevant articles and documents

Synthesis, structure, and biological activity of novel 1H-1,2,4-triazol-1- yl-thiazole derivatives

2-Amino-4-aryl-5-(1H-1,2,4-triazol-1-yl)thiazole derivatives were synthesized from the reaction of α-bromo substituted acetophenone and thiourea. The structures were confirmed by elemental analysis, 1H NMR and single crystal X-ray diffraction analysis. Biological evaluation showed that some of them possess antifungal and plant growth regulatory activities. Copyright Taylor & Francis Group, LLC.