- Methyl 2-Benzoylamino-3-dimethylaminopropenoate in the Synthesis of Heterocyclic Systems. The Synthesis of Substituted 3-Benzoylamino-2H-pyran-2-ones
-
5,6-Disubstituted 3-benzoylamino-2H-pyran-2-ones 3 are prepared either from 1.3-dicarbonyl compounds 1 and methyl 2-benzoyl-amino-3-dimethylaminopropenoate (2) in an one-step reaction or from ethyl 2-acyl-3-dimethylaminopropenoates 5a,b or 2-(dimethylamino)-methylene-1,3-diketones 5c,d and 5-oxo-2-phenyl-1,3-oxazole 6.
- Svete, Jurij,Cadez, Zvonko,Stanovnik, Branko,Tisler, Miha
-
-
Read Online
- Ethyl or methyl 6-substituted 3-(benzoylamino)-2-oxo-2H-pyran-5- carboxylates and 3-(benzoylamino)-7,8-dihydro-2H-1-benzopyran-2,5(6H)-diones with local anesthetic, platelet antiaggregating and other activities
-
The synthesis of ethyl or methyl 6-substituted 3-(benzoylamino)-2-oxo-2H- pyran-5-carboxylates 2 and 3-(benzoylamino)-7,8-dihydro-2H-1-benzopyran- 2,5(6H)-diones 4 by reaction of hippuric acid in acetic anhydride with ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates and 2- dimethylaminomethylene-1,3-cyclohexanediones, respectively, is described. Some compounds 2 and 4 showed a strong local anesthetic activity in mice and a platelet antiaggregating activity in vitro comparable to that of acetylsalicylic acid, as well as moderate analgesic, antiinflammatory and antiarrhythmic activities in rats and mice.
- Mosti,Menozzi,Schenone,D'Amico,Falciani,Rossi
-
-