127168-91-6

Basic information

• Product Name: Methyl 2,3-bis(broMoMethyl)benzoate
• Synonyms: Methyl 2,3-bis(broMoMethyl)benzoate
• CAS NO: 127168-91-6
• Molecular Formula: C₁₀H₁₀Br₂O₂
• Molecular Weight: 321.9932
• Mol File: 127168-91-6.mol

Chemical Properties

• Boiling Point: 375.4 °C at 760 mmHg
• Flash Point: 180.8 °C
• Appearance: /
• Density: 1.728 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2,3-bis(broMoMethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,3-bis(broMoMethyl)benzoate(127168-91-6)
• EPA Substance Registry System: Methyl 2,3-bis(broMoMethyl)benzoate(127168-91-6)

Safety Data

• Hazardous Substances Data: 127168-91-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
Methyl 2,3-bis(bromomethyl)benzoate is used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and materials. Its unique structure and reactivity make it a valuable tool for creating complex organic molecules in the laboratory, contributing to the advancement of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, methyl 2,3-bis(bromomethyl)benzoate is used as a key intermediate in the synthesis of various drugs. Its ability to form complex organic molecules makes it a crucial component in the development of new medications with improved efficacy and safety profiles.
Used in Agrochemical Industry:
Methyl 2,3-bis(bromomethyl)benzoate is also utilized in the agrochemical industry for the synthesis of pesticides and other agricultural chemicals. Its versatility in organic synthesis allows for the development of innovative and effective products to protect crops and enhance agricultural productivity.
Used in Materials Science:
In the field of materials science, methyl 2,3-bis(bromomethyl)benzoate is employed in the synthesis of novel materials with unique properties. Its reactivity and structural features enable the creation of materials with potential applications in various industries, such as electronics, coatings, and adhesives.

Upstream product

• 15012-36-9 methyl 2,3-dimethylbenzoate 
• 186581-53-3 diazomethane 
• 214619-64-4 2,3-Bis-bromomethyl-benzoic acid 
• 603-79-2 2,3-dimethylbenzoic acid 
• 56-23-5 tetrachloromethane 

Downstream Products

• 214619-65-5 2,3-Bis-(diethoxy-phosphorylmethyl)-benzoic acid methyl ester 
• 214619-66-6 2,3-Bis-(diethoxy-phosphorylmethyl)-benzoic acid 
• 2211-83-8 4-methyl-3H-isobenzofuran-1-one 
• 72288-75-6 3-hydroxy-4-methylisobenzofuran-1(3H)-one 
• 127168-92-7 methyl 2-benzylisoindoline-4-carboxylate 
• 533889-80-4 C₂₂H₁₈Cl₂O₄ 

Relevant articles and documents

2-CYANOISOINDOLINE DERIVATIVES FOR TREATING CANCER

The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer.

ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE

Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to amide resorcinol compounds and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.

Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein

Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.

Synthesis of Substrate Analogues and Inhibitors for the Phosphoglycerate Mutase Enzyme

Several substrate analogues of the title enzyme were synthesized as well as with possible irreversible inhibitors, analogues of phosphoglycolate, the cofactor for this enzyme.The main routes involved an Arbuzov type reaction on functionalized halides, a reaction significantly improved by a sonication procedure and reaction of the diethylphosphite anion on tosylates.Phosphorylated epoxides were obtained by quantitative oxidation of conjugate double bonds using DMDO.Preliminary assays indicated a promising activity in some of these compounds.Keywords: phosphonates; inhibitors; phosphoglycerate Mutase; Arbuzov; DMDO

Aromatic Spiranes XXI [1]: Syntheses of Methyl Substituted Phthalaldehydic Acids and their Ethyl and Methyl Esters as Synthones for Syntheses of Methylated 2,2′-Spirobiindandiones

The isomeric methyl phthalaldehydic acids 11 were obtained from phthalides 4 by bromation (NBS) to the 3-bromo derivatives 7 and subsequent hydrolysis with water. 4 in turn were accessible from dimethyl methyl benzoates 1 by dibromination with NBS and subsequent thermical cyclization to the bromo derivatives 3 which, on catalytic dehalogenation, afforded the phthalides 4. Reaction of 11 with methanol or ethanol gave the pseudo-esters 13 and 14, resp. Short treatment of 11 with diazomethane on the other hand yielded the methyl formyl benzoates 15b to 15e. Prolonged reaction (several hours) gave the oxiranyl compounds 17; in addition, the acetonyl derivatives 18 were also found, obviously formed by a double methylene insertion into 15. All reactions proceeded with good to excellent yields.

Isoindoline derivative

Isoindoline derivatives represented by the formula (I) and their salts are disclosed. STR1 There are many varieties for the compound depending on the types of residues R1 -R9 and X. The compounds can be prepared from quinoline derivatives of the formula (II) and an isoindoline derivatives of the formula (III). The compounds of formula (I) and their salts have excellent antibacterial activities against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.