127351-06-8

Basic information

• Product Name: N-(4-bromophenyl)-4-methylbenzenecarbothioamide
• CAS NO: 127351-06-8
• Molecular Formula: C₁₄H₁₂BrNS
• Molecular Weight: 306.2208
• Mol File: 127351-06-8.mol

Chemical Properties

• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 186.6°C
• Density: 1.467g/cm³
• Vapor Pressure: 3.95E-06mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: N-(4-bromophenyl)-4-methylbenzenecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-4-methylbenzenecarbothioamide(127351-06-8)
• EPA Substance Registry System: N-(4-bromophenyl)-4-methylbenzenecarbothioamide(127351-06-8)

Safety Data

• Hazardous Substances Data: 127351-06-8(Hazardous Substances Data)

Upstream product

• 158525-82-7 4-methyl-N-(4-bromophenyl)-benzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 106-40-1 4-bromo-aniline 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 2617-78-9 N-(4-bromophenyl)formamide 
• 104-87-0 4-methyl-benzaldehyde 

Relevant articles and documents

Method for promoting elemental sulfur to synthesize thioamide by mixed alkali in water phase

The invention provides a method for promoting elemental sulfur to synthesize a thioamide compound by a mixed alkali in a water phase, and belongs to the field of organic synthesis. According to the method, an aldehyde compound and an amide compound are us

Mixed bases mediated synthesis of thioamides in water

A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups

Thioamide derivative and preparation method thereof

The invention discloses a thioamide derivative. The structural formula of the thioamide derivative is represented by the formula (I) or the formula (II). The invention also provides a preparation method of the thioamide derivative. According to the preparation method, alkali metal salts are taken as the alkalis, amines are directly coupled with alkenes and sulfur, and by selecting the alkali, twodifferent thioamide derivatives represented by the formula (I) and the formula (II) can be prepared from same raw materials. The provided preparation method has the advantages that the raw materials are cheap and easily available, the synthesis method is simple, and the cost is largely reduced. The provided thioamide derivatives can be used in fields such as bioactive molecules, drug synthesis, and the like, and has a wide application range.

Base-Controlled Three Component Reactions of Amines, Elemental Sulfur, and Styrenes: Synthesis of Thioamides under Metal-Free Conditions

Three component reactions of olefins, amines, and sulfur were studied. Thioamidation of styrenes is base-controlled, and 2-phenylethanethioamides and benzothioamides were obtained selectively in the presence of two different bases. This protocol offers a simple and efficient procedure for the synthesis of thioamides.

Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors

Protein tyrosine kinases occupy a central position in the control of cellular proliferation and its inactivation might lead to the discovery of a new generation anticancer compounds. Substituted benzothiazoles have been found to mimic the ATP-competitive

ANTIMYCOBACTERIAL THIOBENZANILIDES

A group of 30 thiobenzanilides active against Mycobacterium kansasii have been synthesized and their 1H NMR and UV spectra and RM values (TLC on silica gel impregnated with methylsilicone oil) have been measured.From the correlation between the chemical shifts of the thioamide proton in the 1H NMR spectra and the Hammett constants it can be concluded that the substituents in both aromatic rings uniformly affect the electron density of the thioamide group.The antimycobacterial activity is probably connected with local molecular parameters and can be considered to be approximately additive with respect to both parts of the molecule.