1273564-99-0 Usage
Uses
Used in Pharmaceutical Industry:
3,3-difluorocyclobutanone is used as a synthetic intermediate for the production of various pharmaceuticals. Its incorporation into drug molecules can improve their efficacy and pharmacokinetic properties, such as solubility, lipophilicity, and metabolic stability.
Used in Agrochemical Industry:
In the agrochemical industry, 3,3-difluorocyclobutanone serves as a key intermediate in the synthesis of agrochemicals, including pesticides and herbicides. The introduction of fluorine atoms can enhance the biological activity and selectivity of these compounds, leading to more effective and environmentally friendly products.
Used in Organic Synthesis:
3,3-difluorocyclobutanone is employed as a reagent in organic synthesis to introduce fluorine atoms into organic molecules. The presence of fluorine can significantly alter the physical, chemical, and biological properties of the resulting compounds, making them more suitable for various applications, such as drug development or material science.
Due to its high reactivity, 3,3-difluorocyclobutanone requires careful handling and specialized equipment for its synthesis and use in chemical reactions. This ensures the safety of the process and the quality of the final products.
Check Digit Verification of cas no
The CAS Registry Mumber 1273564-99-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,3,5,6 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1273564-99:
(9*1)+(8*2)+(7*7)+(6*3)+(5*5)+(4*6)+(3*4)+(2*9)+(1*9)=180
180 % 10 = 0
So 1273564-99-0 is a valid CAS Registry Number.
1273564-99-0Relevant articles and documents
Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks
Melnykov, Kostiantyn P.,Granat, Dmitriy S.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.
, p. 4949 - 4957 (2018)
An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.
