- Flexibly labeling peptides
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A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the amino-chelator loaded resin to the C-terminus and/or backbone
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Page/Page column 6
(2010/11/30)
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- A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe
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An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled
- Yoo, Byunghee,Pagel, Mark D.
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p. 7327 - 7330
(2007/10/03)
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- Azabicycloalkenes as synthetic intermediates: Application to the preparation of diazabicycloalkane scaffolds
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A general method to synthesize bicyclic dipeptide mimetics is reported. Key intermediates are azabicycloalkenes 9 and 17, which are prepared via Diels-Alder reactions and subsequent mild deprotection. These unsaturated bicyclic heterocycles are versatile
- Prenzel, Alexander H. G. P.,Deppermann, Nina,Maison, Wolfgang
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p. 1681 - 1684
(2007/10/03)
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- CONVERSION OF SERINE AND THREONINE RESIDUES INTO α-ACYLOXY-, α-ALKYLTHIO-, AND α-HALOGENOGLYCINE MOIETIES: A NEW STRATEGY FOR THE MODIFICATION OF PEPTIDES
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Selective modification of serine and threonine containing peptides is accomplished by oxidation with lead tetraacetate.Conversion of the derived α-acetoxyglycine derivative into α-alkylthio- and α-halogenoglycine residues offers a novel synthetic route to
- Apitz, Gregor,Steglich, Wolfgang
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p. 3163 - 3166
(2007/10/02)
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- General Synthesis of β,γ-Alkynylglycine Derivatives
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The coupling of α-haloglycinates 8 with alkynyltin reagents produces the fully protected β,γ-alkynylglycines 9.Subsequent deprotection of the amino or carboxyl groups generates differentially protected β,γ-alkynylglycine derivatives 10-14.The free amino a
- Williams, Robert M.,Aldous, David J.,Aldous, Suzanne C.
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p. 4657 - 4663
(2007/10/02)
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