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5-Hydroxy-6-methoxy-1-indanone, with the CAS number 127399-78-4, is a light-brown solid compound that is valuable in the field of organic synthesis. It is characterized by its unique chemical structure, which contributes to its potential applications in various industries.

127399-78-4

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127399-78-4 Usage

Uses

Used in Organic Synthesis:
5-Hydroxy-6-methoxy-1-indanone is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows it to be a versatile building block in the creation of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Hydroxy-6-methoxy-1-indanone is used as a starting material for the development of new drugs. Its chemical properties make it suitable for the synthesis of complex molecular structures that can target specific biological pathways, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
5-Hydroxy-6-methoxy-1-indanone is also utilized in the agrochemical industry for the synthesis of various pesticides and other crop protection agents. Its structural diversity enables the development of new compounds with improved efficacy and selectivity, contributing to more sustainable agricultural practices.
Used in Specialty Chemicals:
In the specialty chemicals sector, 5-Hydroxy-6-methoxy-1-indanone is employed as a precursor for the production of various high-value chemicals. These can include dyes, fragrances, and other additives that are used across different industries, such as textiles, cosmetics, and plastics.
Overall, 5-Hydroxy-6-methoxy-1-indanone is a versatile compound with a wide range of applications in various industries, primarily due to its unique chemical structure and properties. Its use in organic synthesis, pharmaceuticals, agrochemicals, and specialty chemicals highlights its potential as a valuable building block in the development of new and innovative products.

Check Digit Verification of cas no

The CAS Registry Mumber 127399-78-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,3,9 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127399-78:
(8*1)+(7*2)+(6*7)+(5*3)+(4*9)+(3*9)+(2*7)+(1*8)=164
164 % 10 = 4
So 127399-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O3/c1-13-10-5-7-6(4-9(10)12)2-3-8(7)11/h4-5,12H,2-3H2,1H3

127399-78-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-hydroxy-6-methoxy-2,3-dihydroinden-1-one

1.2 Other means of identification

Product number -
Other names 5-hydroxy-6-methoxy-indan-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127399-78-4 SDS

127399-78-4Relevant articles and documents

cGAS ANTAGONIST COMPOUNDS

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Paragraph 0477, (2017/11/06)

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Recyclable Hypervalent-Iodine-Mediated Dehydrogenative α,β′-Bifunctionalization of β-Keto Esters under Metal-Free Conditions

Duan, Ya-Nan,Cui, Li-Qian,Zuo, Lin-Hong,Zhang, Chi

supporting information, p. 13052 - 13057 (2015/09/07)

We have developed a method for recyclable hypervalent-iodine-mediated direct dehydrogenative α,β′- bifunctionalization of β-ketoesters and β-diketones under metal-free conditions, which affords a straightforward way to synthesize benzo-fused 2,3-dihydrofurans. This efficient, mild method, which has a wide substrate scope and good functional-group tolerance, was used for the multistep synthesis of the protected aglycone of a naturally occurring phenolic glycoside. A mechanism involving Michael addition to an enone intermediate and subsequent oxidative cyclization is proposed.

Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, Mathew P.,Jourdan, Fabrice L.,Major, Meriel R.,Dohle, Wolfgang,Thomas, Mark P.,Hamel, Ernest,Ferrandis, Eric,Mahon, Mary F.,Newman, Simon P.,Purohit, Atul,Potter, Barry V. L.

supporting information, p. 798 - 812 (2014/05/06)

A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)-based steroidomimetic microtubule disruptors has been extended to dihydroisoquinolinone (DHIQ)-based compounds. A steroid A,B-ring-mimicking DHIQ core was connected to

ISOQUINOLINE AMINOPYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CANCER

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Page/Page column 246-247, (2008/06/13)

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Tong, Yunsong,Przytulinska, Magdalena,Tao, Zhi-Fu,Bouska, Jennifer,Stewart, Kent D.,Park, Chang,Li, Gaoquan,Claiborne, Akiyo,Kovar, Peter,Chen, Zehan,Merta, Philip J.,Bui, Mai-Ha,Olson, Amanda,Osterling, Donald,Zhang, Haiying,Sham, Hing L.,Rosenberg, Saul H.,Sowin, Thomas J.,Lin, Nan-horng

, p. 5665 - 5670 (2008/03/14)

A series of 1,4-dihydroindeno[1,2-c]pyrazole compounds with a cyanopyridine moiety at the 3-position of the tricyclic pyrazole core was explored as potent CHK-1 inhibitors. The impact of substitutions at the 6 and/or 7-position of the core on pharmacokinetic properties was studied in detail. Compounds carrying a side chain with an ether linker at the 7-position and a terminal morpholino group, such as 29 and 30, exhibited much-improved oral biovailability in mice as compared to earlier generation inhibitors. These compounds also possessed desirable cellular activity in potentiating doxorubicin and will serve as valuable tool compounds for in vivo evaluation of CHK-1 inhibitors to sensitize DNA-damaging agents.

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Tao, Zhi-Fu,Li, Gaoquan,Tong, Yunsong,Chen, Zehan,Merta, Philip,Kovar, Peter,Zhang, Haiying,Rosenberg, Saul H.,Sham, Hing L.,Sowin, Thomas J.,Lin, Nan-Horng

, p. 4308 - 4315 (2008/02/09)

A new series of potent tricyclic pyrazole-based Chk1 inhibitors are described. Analogues disubstituted on the 6- and 7-positions show improved Chk1 inhibition potency compared with analogues with a single substituent on either the 6- or 7-position. Based

IMMOBILIZED N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES FOR THE IDENTIFICATION OF BIOMOLECULAR TARGETS

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Page/Page column 131, (2008/06/13)

The present invention relates to immobilized N-substituted tricyclic 3-aminopyrazole compounds of Formula 1 as tools for the identification of bimolecular targets in cells of therapeutic significance, profiling the selectivity of compounds, prediction of

Cleavage of aromatic methyl ethers by chloroaluminate ionic liquid reagents

Kemperman, Gerardus J.,Roeters, Theodorus A.,Hilberink, Peter W.

, p. 1681 - 1686 (2007/10/03)

We have discovered serendipitously that chloroaluminate ionic liquids can cleave aromatic methyl ethers under surprisingly mild conditions. Three ionic liquids, viz. [TMAH]-[Al2Cl7], [BMIM][Al2Cl7], and [EMIM][Al2Cl6I], and aluminum chloride were compared in the selective demethylation of 4,5-dimethoxyindanone at the 4-methoxy-function. The ionic liquids exhibited a remarkably high selectivity (96:4) in comparison with aluminum chloride (70:30). In addition, the reaction time was drastically shortened when the ionic liquids were used. Interestingly, the three ionic liquids displayed the same reactivity in the demethylation of 4,5-dimethoxyindanone. Considering the lower cost and the bulk availability of the precursors of [TMAH][Al2Cl7], we conclude that this is the most attractive ionic liquid from an industrial point of view. To make the large-scale application of [TMAH][Al2Cl7] feasible, we have developed a safe upscalable method for its preparation. Furthermore, the scope of ether cleavage by the ionic liquid reagent [TMAH][Al2Cl7] was investigated and it was found that aromatic methyl-, al- lyl-, and benzyl-ether cleavage is applicable to a variety of heterocyclic compounds. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

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