68360-26-9Relevant academic research and scientific papers
Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones
Leese, Mathew P.,Jourdan, Fabrice L.,Major, Meriel R.,Dohle, Wolfgang,Thomas, Mark P.,Hamel, Ernest,Ferrandis, Eric,Mahon, Mary F.,Newman, Simon P.,Purohit, Atul,Potter, Barry V. L.
, p. 798 - 812 (2014/05/06)
A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)-based steroidomimetic microtubule disruptors has been extended to dihydroisoquinolinone (DHIQ)-based compounds. A steroid A,B-ring-mimicking DHIQ core was connected to
