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127446-42-8

6-Chloro-1,8-Naphthyridin-2-One is a heterocyclic chemical compound characterized by a naphthyridine core structure with a chlorine atom attached at the 6th position. With the molecular formula C10H5ClN2O, this compound has been recognized for its potential pharmaceutical applications, particularly in the development of anti-bacterial and anti-inflammatory drugs. Its unique chemical properties position it as a promising candidate for further research and development within the pharmaceutical industry. The presence of a chlorine atom in the compound also facilitates its use in various chemical reactions and modifications, broadening its scope in drug development and other related fields.

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  • 127446-42-8 Structure

  • Basic information

    1. Product Name: 6-Chloro-1,8-Naphthyridin-2-One
    2. Synonyms: 6-Chloro-1,8-phthyridin-2(1H)-one;1,8-Naphthyridin-2(1H)-one,6-chloro-;6-Chloro-1,8-Naphthyridin-2-One
    3. CAS NO:127446-42-8
    4. Molecular Formula: C8H5ClN2O
    5. Molecular Weight: 180.5911
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 127446-42-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.419
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-Chloro-1,8-Naphthyridin-2-One(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-Chloro-1,8-Naphthyridin-2-One(127446-42-8)
    11. EPA Substance Registry System: 6-Chloro-1,8-Naphthyridin-2-One(127446-42-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127446-42-8(Hazardous Substances Data)

127446-42-8 Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-1,8-Naphthyridin-2-One is utilized as a key intermediate in the synthesis of various pharmaceutical compounds for its potential anti-bacterial and anti-inflammatory properties. Its unique structure and chemical properties make it a valuable component in the development of new drugs that can address unmet medical needs.
Used in Drug Development:
In the drug development process, 6-Chloro-1,8-Naphthyridin-2-One serves as a building block for the creation of novel therapeutic agents. Its chemical reactivity, particularly due to the presence of the chlorine atom, allows for further functionalization and optimization of drug candidates to enhance their efficacy, selectivity, and pharmacokinetic properties.
Used in Chemical Reactions and Modifications:
6-Chloro-1,8-Naphthyridin-2-One is employed as a versatile reactant in various chemical reactions, enabling the synthesis of a wide range of derivatives with diverse biological activities. The chlorine atom in the compound can be replaced or modified through substitution reactions, allowing for the exploration of structure-activity relationships and the discovery of new lead compounds with improved pharmacological profiles.
Used in Research and Development:
6-Chloro-1,8-Naphthyridin-2-One is used as a research tool in academic and industrial laboratories to study the structure-activity relationships of naphthyridine-based compounds. Its unique chemical properties and potential biological activities make it an attractive target for the development of new therapeutic agents and the advancement of medicinal chemistry knowledge.

Check Digit Verification of cas no

The CAS Registry Mumber 127446-42-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,4 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 127446-42:
(8*1)+(7*2)+(6*7)+(5*4)+(4*4)+(3*6)+(2*4)+(1*2)=128
128 % 10 = 8
So 127446-42-8 is a valid CAS Registry Number.

127446-42-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-1H-1,8-naphthyridin-2-one

1.2 Other means of identification

Product number -
Other names 6-Chloro-1,8-naphthyridin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127446-42-8 SDS

127446-42-8Downstream Products

127446-42-8Relevant articles and documents

A General Approach to the Synthesis of 1,6-, 1,7-, and 1,8-Naphthyridines

Turner, James A.

, p. 4744 - 4750 (2007/10/02)

A new three-step procedure for pyridine annulation is described and illustrated with efficient syntheses of various 1,6-, 1,7-, and 1,8-naphthyridin-2-ones as well as 6-chloroquinolin-2-one.The regiospecific ortho metalation and subsequent formylation of

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