- DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
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The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5'; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
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Page/Page column 30
(2016/03/22)
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- 1,2-H shift in copper-chlorocarbenoid intermediate during CuCl/bpy-promoted stereoselective dechlorination of 2,2,2-trichloroethyl alkyl ethers to (Z)-1-alkoxy-2-chloroethenes
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(Chemical Equation Presented) Reaction of 2,2,2-trichloroethyl alkyl ethers with 2 molar equiv of CuCl/bpy in refluxing DCE yielded (Z)-1-alkoxy-2- chloroethenes stereoselectively as the major product via 1,2-H shift in copper-chlorocarbenoid intermediate. 2,2,2-Trichloroethyl carboxylates undergo a radical 1,2-acyloxy shift under similar conditions.
- Ram, Ram N.,Manoj
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supporting information; experimental part
p. 2243 - 2246
(2009/05/11)
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- Chemical compounds
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Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
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- Process for preparing alkyl- or aryloxyacetaldehydes
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A process for preparing alkyl- or aryloxyacetaldehydes of the formula where R can be an unsubstituted or mono- or polysubstituted alkyl, aryl, heteroaryl, alkaryl, alkylheteroaryl or aralkyl radical or an unsubstituted or mono- or polysubstituted heterocycle or alkyl heterocycle, which comprises reacting a compound of the formula R—OM??(II) where R is as defined above and M can be an alkali metal atom or an alkaline earth metal atom, with a compound of the formula where R1 and R2 independently of one another are a C1-C6-alkyl radical or together are a C2-C6-alkylene radical and X is a halogen atom, to form the corresponding dialkylacetal of the formula where R, R1 and R2 are as defined above, whereupon acetal cleavage is carried out to give the desired alkyl- or aryloxyacetaldehydes of the formula (I).
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- Remote Asymmetric Induction in Diastereoface Selective Addition Reactions of Optically Active α-Substituted-β-silyl (E)-Hexenoates with Achiral α-Alkoxy and β-Alkoxy Acetals
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Optically active and diastereomerically pure (E)-crotylsilanes 1 function as effective chiral carbon nucleophiles in trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed asymmetric addition reactions of achiral, α-alkoxy and β-alkoxy acetals 2, res
- Panek, James S.,Yang, Michael
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p. 5755 - 5758
(2007/10/02)
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