128071-84-1

Basic information

• Product Name: 4-Bromo-2-chloropyridine-3-carboxaldehyde
• Synonyms: 4-Bromo-2-chloropyridine-3-carboxaldehyde;4-Bromo-2-chloro-3-formylpyridine;4-Bromo-2-chloronicotinaldehyde;4-Bromo-2-chloropyridine-3-carbaldehyde
• CAS NO: 128071-84-1
• Molecular Formula: C₆H₃BrClNO
• Molecular Weight: 220.45
• Mol File: 128071-84-1.mol

Chemical Properties

• Melting Point: 80-85°C
• Boiling Point: 291.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.800±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.25±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-chloropyridine-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-chloropyridine-3-carboxaldehyde(128071-84-1)
• EPA Substance Registry System: 4-Bromo-2-chloropyridine-3-carboxaldehyde(128071-84-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 128071-84-1(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-chloropyridine-3-carbaldehyde is used in the synthesis of N-protected aromatic-ring fused pyrrole-2-carboxylate derivatives.

Upstream product

• 73583-37-6 2-chloro-4-bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 52200-48-3 3-bromo-2-chloropyridine 

Downstream Products

• 1240618-32-9 (4-bromo-2-fluoropyridin-3-yl)methanol 
• 1418287-34-9 1-tert-butyl 2-methyl 4-chloro-1H-pyrrolo[3,2-c]pyridine-1,2-dicarboxylate 

Relevant articles and documents

HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.