4-Bromo-2-chloropyridine-3-carboxaldehyde

Base Information

• Chemical Name: 4-Bromo-2-chloropyridine-3-carboxaldehyde
• CAS No.: 128071-84-1
• Molecular Formula: C6H3BrClNO
• Molecular Weight: 220.45100
• Hs Code.: 2933399090
• European Community (EC) Number: 694-558-8
• DSSTox Substance ID: DTXSID60704431
• Wikidata: Q82636853
• Mol file: 128071-84-1.mol

Synonyms:4-Bromo-2-chloropyridine-3-carboxaldehyde;128071-84-1;4-bromo-2-chloropyridine-3-carbaldehyde;4-BROMO-2-CHLORONICOTINALDEHYDE;3-Pyridinecarboxaldehyde, 4-bromo-2-chloro-;SCHEMBL14912102;DTXSID60704431;KHGMGNDNTOOOLP-UHFFFAOYSA-N;MFCD11044270;AKOS016002637;AB62918;AC-33516;AS-36681;CS-0139521;FT-0697518;EN300-128602;4-Bromo-2-chloropyridine-3-carboxaldehyde, 96%;A889097

Chemical Property of 4-Bromo-2-chloropyridine-3-carboxaldehyde

Chemical Property:

• Melting Point: 80-85°C
• Boiling Point: 291.7±35.0 °C(Predicted)
• PKA: -1.25±0.10(Predicted)
• PSA: 29.96000
• Density: 1.800±0.06 g/cm3(Predicted)
• LogP: 2.31000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 218.90865
• Heavy Atom Count: 10
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-chloropyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Br)C=O)Cl
• Uses: 4-Bromo-2-chloropyridine-3-carbaldehyde is used in the synthesis of N-protected aromatic-ring fused pyrrole-2-carboxylate derivatives.

Technology Process of 4-Bromo-2-chloropyridine-3-carboxaldehyde

There total 2 articles about 4-Bromo-2-chloropyridine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

2-chloro-4-bromopyridine (73583-37-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → bromo-4 chloro-2 formyl-3 pyridine (128071-84-1)

Guidance literature:

2-chloro-4-bromopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 2.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; for 0.666667h;

Reference yield:

3-bromo-2-chloropyridine (52200-48-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → bromo-4 chloro-2 formyl-3 pyridine (128071-84-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0022-328X(90)80210-Q

Reference yield: 93.0%

diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate (916203-67-3) + bromo-4 chloro-2 formyl-3 pyridine (128071-84-1) → (2E)-3-(4-bromo-2-chloropyridin-3-yl)-N-(2,6-dichlorophenyl)acrylamide

Guidance literature:

diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate; With potassium tert-butylate; In tetrahydrofuran; for 1.5h;

bromo-4 chloro-2 formyl-3 pyridine; In tetrahydrofuran; at 22 ℃; for 2.5h;

DOI:10.1021/jo0613479

upstream raw materials:

3-bromo-2-chloropyridine

N,N-dimethyl-formamide

2-chloro-4-bromopyridine

Downstream raw materials:

1-tert-butyl 2-methyl 4-chloro-1H-pyrrolo[3,2-c]pyridine-1,2-dicarboxylate

(4-bromo-2-fluoropyridin-3-yl)methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 128071-84-1 4-Bromo-2-chloropyridine-3-carboxaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send