128073-16-5

Basic information

• Product Name: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER
• Synonyms: ETHYL 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXYLATE;ETHYL 3-CHLORO-5-(TRIFLUOROMETHYL)PICOLINATE;2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER;3-Chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester;Ethyl 5-(trifluoroMethyl)-3-chloropyridine-2-carboxylate;3-Chloro-5-(trifluoroMethyl)2-pyridinecarboxylic acid ethyl ester;3-Chloro-2-(ethoxycarbonyl)-5-(trifluoromethyl)pyridine, Ethyl 3-chloro-5-(trifluoromethyl)picolinate;3- chloro -5- three fluoromethyl pyridine -2- formate
• CAS NO: 128073-16-5
• Molecular Formula: C9H7ClF3NO2
• Molecular Weight: 253.61
• Product Categories: Pyridines
• Mol File: 128073-16-5.mol

Chemical Properties

• Boiling Point: 64-66℃/0.008mm
• Flash Point: 121.2 °C
• Appearance: /
• Density: 1.389 g/cm³
• Vapor Pressure: 0.0047mmHg at 25°C
• Refractive Index: 1.4590 to 1.4630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.19±0.10(Predicted)
• CAS DataBase Reference: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(128073-16-5)
• EPA Substance Registry System: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER(128073-16-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 128073-16-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique chemical properties and reactivity allow for the creation of novel drug candidates with potential therapeutic applications.
Used in Agricultural Chemical Industry:
In the agricultural chemical industry, 2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester serves as a key intermediate in the synthesis of various agrochemicals. Its chemical structure and properties enable the production of effective compounds for pest control and crop protection.
Used in Chemical Research and Development:
2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester is utilized in the chemical research and development sector for the exploration of new materials and compounds. Its synthesis and properties are subjects of ongoing research, driving innovation and advancements in the chemical industry.

InChI:InChI=1/C9H7ClF3NO2/c1-2-16-8(15)7-6(10)3-5(4-14-7)9(11,12)13/h3-4H,2H2,1H3

Upstream product

• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 80194-70-3 3-chloro-2-cyano-5-(trifluoromethyl)pyridine 

Downstream Products

• 80194-68-9 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid 
• 172527-65-0 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-3-cyclopropylpropan-13-dione 
• 1245784-27-3 ethyl 3-methanesulfonyl-5-trifluoromethylpyridine-2-carboxylate 
• 1033463-30-7 3-chloro-5-(trifluoromethyl)picolinohydrazide 

Relevant articles and documents

3 - chloro -5 - trifluoromethyl pyridine compounds and intermediates method (by machine translation)

The invention discloses a 3 - chloro -5 - trifluoromethyl pyridine compound and preparation method of the midbody. The invention of the formula 3 a compound represented by the preparation method, comprising the following steps: organic solvent and water in the mixed solvent, under the action of the phase transfer catalyst, shown as 2 shown with the metal cyanide compounds of the substitution reaction, carbonized 3 compound of formula; further comprises the following steps: in the solvent, under the effect of the fluorination reagent, shown as 1 shown in the fluorination reaction of the compound, prepared states like the type 2 compound of formula; and can also be further comprises the following steps: under the action of the hydrogen and ethanol, shown as 3 shown in the Pinner reaction compound, then hydrolyzing the ester reaction, carbonized 4 compounds are shown. The invention of 3 - chloro -5 - trifluoromethyl pyridine compound preparation method of low cost, high production safety, simple operation, high yield, it is suitable for industrial production. (by machine translation)

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Synthetic process development and scale up of palladium-catalyzed alkoxycarbonylation of chloropyridines

2,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alcohol, and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate.

Pyrazole derivatives as herbicides

Compounds of the following formula I wherein wherein all variables are as defined in the specification and the pyrazoleN-oxides, agrochemically acceptable salts and stereisomers thereof useful as herbisdes.

Novel herbicides

The invention relates to novel herbicidally active cyclohexanediones of formula I or I' STR1 in which R1 and R2 independently of one another are each hydrogen; halogen; nitro; cyano; C1 -C4 alkyl; C1 -C4 alkoxy; C1 -C4 alkyl-S(O)n --; COR8 ; C1 -C4 haloalkoxy; or C1 -C4 haloalkyl; R3, R4 and R5 independently of one another are each hydrogen; C1 -C4 alkyl; or phenyl or benzyl each unsubstituted or substituted by up to three identical or different substituents from halogen, nitro, cyano, C1 -C4 alkyl, C1 -C4 alkoxy, C1 -C4 alkyl-S(O)n --, C1 -C4 haloalkyl, C1 -C4 haloalkyl-S(O)n -- and C1 -C4 haloalkoxy; R6 is hydrogen; C1 -C4 alkyl, C1 -C4 alkoxycarbonyl; or cyano; R7 is OH; or O? M≈ ; R8 is OH; C1 -C4 alkoxy; NH2 ; C1 -C4 alkylamino; or di-C1 - C4 alkylamino; n is 0, 1 or 2; M+ is a cation equivalent of a metal ion or of an ammonium ion that is unsubstituted or substituted by up to three C1 -C4 alkyl, C1 -C4 hydroxyalkyl or C1 -C4 alkoxy-C1 -C4 alkyl groups, to herbicidal compositions, to processes for the preparation of novel compounds and to novel intermediates and the preparation thereof.