80194-68-9

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid is utilized as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new therapeutic agents with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Agrochemical Production:
In the agrochemical sector, 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid is employed as a building block for the creation of novel pesticides and herbicides. Its reactivity and structural features enable the design of more effective and environmentally friendly agrochemicals, contributing to sustainable agricultural practices.
Used in Organic Chemistry Research:
3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid serves as a valuable research tool in organic chemistry. Its diverse reactivity and functional groups make it an ideal candidate for exploring new synthetic pathways, developing innovative reaction mechanisms, and expanding the scope of organic transformations.
Used in Medicinal Chemistry Development:
In the field of medicinal chemistry, 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid is leveraged as a starting material for the design and synthesis of new bioactive compounds with potential therapeutic applications. Its unique structural features facilitate the development of molecules with novel modes of action and improved pharmacological profiles, advancing the discovery of new drugs for the treatment of various diseases.

InChI:InChI=1/C7H3ClF3NO2/c8-4-1-3(7(9,10)11)2-12-5(4)6(13)14/h1-2H,(H,13,14)

Upstream product

• 128073-16-5 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester 
• 80194-70-3 3-chloro-2-cyano-5-(trifluoromethyl)pyridine 
• 923251-81-4 ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate 
• 75806-84-7 2-bromo-3-chloro-5-(trifluoromethyl)pyridine 

Downstream Products

• 80194-72-5 3-chloro-5-trifluoromethyl-2-pyridinecarboxylic acid chloride 
• 1624603-50-4 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-(trifluoromethyl)picolinamide 
• 338758-69-3 3-chloro-5-(trifluoromethyl)picolinamide 
• 1624604-86-9 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-3-chloro-5-(trifluoromethyl)picolinamide 

Relevant academic research and scientific papers

Preparative method for carboxylic acids

A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), as represented by the following reaction scheme: wherein R1 is aryl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, thiadiazolyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl and hydrogen; R2 is alkoxycarbonyl, alkylaminocarbonyl, aminocarbonyl, alkylthiolcarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, aldehyde, carboxyl, nitro, alkyl and hydrogen; R3 is alkoxycarbonyl, alkyl amido carbonyl, aminocarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, carboxyl and nitro. The present invention has the following main benefits: cheap and readily available starting materials, safe processes, high yield, good quality, which facilitates industrial production.

COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES

The invention provides novel tricyclic compounds of Formula (I) that inhibit β- secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.

Pyrazole derivatives as herbicides

Compounds of the following formula I wherein wherein all variables are as defined in the specification and the pyrazoleN-oxides, agrochemically acceptable salts and stereisomers thereof useful as herbisdes.

Novel herbicides

The invention relates to novel herbicidally active cyclohexanediones of formula I or I' STR1 in which R1 and R2 independently of one another are each hydrogen; halogen; nitro; cyano; C1 -C4 alkyl; C1 -C4 alkoxy; C1 -C4 alkyl-S(O)n --; COR8 ; C1 -C4 haloalkoxy; or C1 -C4 haloalkyl; R3, R4 and R5 independently of one another are each hydrogen; C1 -C4 alkyl; or phenyl or benzyl each unsubstituted or substituted by up to three identical or different substituents from halogen, nitro, cyano, C1 -C4 alkyl, C1 -C4 alkoxy, C1 -C4 alkyl-S(O)n --, C1 -C4 haloalkyl, C1 -C4 haloalkyl-S(O)n -- and C1 -C4 haloalkoxy; R6 is hydrogen; C1 -C4 alkyl, C1 -C4 alkoxycarbonyl; or cyano; R7 is OH; or O? M≈ ; R8 is OH; C1 -C4 alkoxy; NH2 ; C1 -C4 alkylamino; or di-C1 - C4 alkylamino; n is 0, 1 or 2; M+ is a cation equivalent of a metal ion or of an ammonium ion that is unsubstituted or substituted by up to three C1 -C4 alkyl, C1 -C4 hydroxyalkyl or C1 -C4 alkoxy-C1 -C4 alkyl groups, to herbicidal compositions, to processes for the preparation of novel compounds and to novel intermediates and the preparation thereof.

2-Substituted-5-trifluoromethylpyridines and process for producing the same

A 2-substituted-5-trifluoromethylpyridine compound represented by Formula (I): STR1 wherein X is a hydrogen atom or a halogen atom, and Y is a cyano group or a carboxy group, provided that Y is a cyano group, then X is a halogen atom, or a salt thereof, and a process for the production of the same. This compound is useful as an intermediate for the production of various fine chemicals.