128114-99-8

Basic information

• Product Name: (2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one
• CAS NO: 128114-99-8
• Molecular Formula: C₂₉H₂₅FN₂O₄
• Molecular Weight: 484.5182
• Mol File: 128114-99-8.mol

Chemical Properties

• Boiling Point: 598.2°C at 760 mmHg
• Flash Point: 315.6°C
• Density: 1.31g/cm³
• Vapor Pressure: 2.86E-14mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: (2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one(128114-99-8)
• EPA Substance Registry System: (2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one(128114-99-8)

Safety Data

• Hazardous Substances Data: 128114-99-8(Hazardous Substances Data)

Usage

Uses

Used in Synthetic Organic Chemistry:
(2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one is used as a protecting group for alcohols in synthetic organic chemistry due to its trityl ether functional group. This application is crucial for the synthesis of complex organic molecules where the protection of functional groups is necessary to prevent unwanted reactions.
Used in Pharmaceutical and Medicinal Research:
In the pharmaceutical and medicinal research industry, (2R,3R,5S,11S)-11-fluoro-8-methyl-3-[(trityloxy)methyl]-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one is utilized for its potential to contribute to the development of new drugs. Its unique structure and reactivity allow it to be explored for various therapeutic applications, including the treatment of diseases and disorders that require innovative molecular solutions.

Upstream product

• 128114-98-7 1-(2-deoxy-2-fluoro-3-O-mesyl-5-O-triphenylmethyl-β-D-arabinofuranosyl)thymine 
• 76-83-5 trityl chloride 
• 69256-17-3 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine 
• 128114-97-6 1-(2-deoxy-2-fluoro-5-O-trityl-β-D-arabinofuranosyl)thymine 

Downstream Products

• 128496-21-9 1-(3-deoxy-2,3-didehydro-2-fluoro-5-O-trityl-β-D-glycero-2-enopentofuranosyl)thymine 
• 124424-26-6 1-(3-azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine 

Relevant articles and documents

Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

The disclosed invention is a composition for and a method of seating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction (“RT-PCR”). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.

Fluorinated sugar analogues of potential anti-HIV-1 nucleosides

In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met

Synthesis and anti-HIV-1 activity of 2'-'up'-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC)

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (6, F-AZT) and 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12, F-DDC) were synthesized from the potent antiherpes virus nucleosides 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine