128114-98-7 Usage
Chemical structure
A synthetic derivative of the naturally occurring nucleoside cytidine, with modifications to the 2'-hydroxyl group and additional functional groups.
2'-hydroxyl group substitution
The 2'-hydroxyl group is replaced with a 2'-deoxy-2-fluoro group, which enhances nuclease stability and incorporation into DNA and RNA.
Fluorine atom
Presence of a fluorine atom at the 2' position, which contributes to the improved stability and biological activity of the compound.
Methylsulfonyl group
The 3' position contains a methylsulfonyl group, which may play a role in the compound's antiviral and antineoplastic activities.
Trityl group
A trityl (triphenylmethyl) group is attached to the 5' position, which can provide steric protection and may influence the compound's interactions with enzymes and other biomolecules.
Pyrimidine base
The compound features a 5-methylpyrimidine base, which is a common structural element in many nucleoside analogs and may contribute to its biological activity.
Carbonyl groups
The presence of two carbonyl groups at the 2 and 4 positions of the pyrimidine ring, which are typical of pyrimidine nucleoside analogs and may be involved in interactions with target enzymes.
Antineoplastic activity
The compound also has potential antineoplastic (anticancer) properties, although the exact mechanisms of action are not yet fully understood.
Further research
More research is needed to fully understand the compound's mechanisms of action, potential therapeutic applications, and any possible side effects or limitations in its use.
Check Digit Verification of cas no
The CAS Registry Mumber 128114-98-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,1,1 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 128114-98:
(8*1)+(7*2)+(6*8)+(5*1)+(4*1)+(3*4)+(2*9)+(1*8)=117
117 % 10 = 7
So 128114-98-7 is a valid CAS Registry Number.
128114-98-7Relevant articles and documents
Fluorinated sugar analogues of potential anti-HIV-1 nucleosides
Huang,Chen,Wang,Kim,Warshaw,Armstrong,Zhu,Chou,Watanabe,Matulic-Adamic,Su,Fox,Polsky,Baron,Gold,Hardy,Zuckerman
, p. 1640 - 1646 (2007/10/02)
In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met
Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)
Martin,Bushnell,Duncan,Dunsdon,Hall,Machin,Merrett,Parkes,Roberts,Thomas,Galpin,Kinchington
, p. 2137 - 2145 (2007/10/02)
A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluaed against human immunodeficiency virus (HIV-1) in a human lymphoblastoid cell line. Among these compounds, 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12), 2',3'-didehydro-2',3'-dideoxy-2'-fluorocytidine (35), 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)cytosine (41), and 3'-deoxy-2',3'-didehydro-2'-fluorothymidine (45) were found to have significant antiviral activity, with IC50 values of 0.65, 10, 10, and 100 μM, respectively. The structure-activity relationships are discussed.
