128228-96-6

Basic information

• Product Name: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole
• Synonyms: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole;3-(Thiophen-2-yl)-5-(trifluoroMethyl)-1H-pyrazole
• CAS NO: 128228-96-6
• Molecular Formula: C₈H₅F₃N₂S
• Molecular Weight: 218.1989096
• EINECS: -0
• Mol File: 128228-96-6.mol

Chemical Properties

• Boiling Point: 335.7°Cat760mmHg
• Flash Point: 156.8°C
• Appearance: /
• Density: 1.461g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole(128228-96-6)
• EPA Substance Registry System: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole(128228-96-6)

Safety Data

• Hazardous Substances Data: 128228-96-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole is used as a potential candidate for the development of new drugs due to its pharmacological properties. Its unique structure may offer novel therapeutic applications, and further research is required to explore its full potential in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole may serve as a building block or intermediate in the synthesis of agrochemicals, potentially contributing to the development of new pesticides or herbicides.
Used in Materials Science:
5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole is used for the synthesis of new materials or as a component in existing materials, leveraging its unique structural and chemical attributes to enhance material properties or create novel materials with specific characteristics.
Further research and exploration of 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole's properties and potential applications across different industries are essential to fully understand its significance and harness its potential in various applications.

Upstream product

• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 

Downstream Products

• 1570067-43-4 C₂₂H₁₃F₃N₂S 

Relevant articles and documents

Reductive deacetylation of 3,3,3-trifluoro-1-(2-thenoyl)acetone

The reaction of 3,3,3-trifluoro-1-(2-thenoyl)acetone with sulfur-hydrazine hydrate-alkali and hydrazine hydrate-alkali systems is effected by reductive fission of the trifluoroacetyl group and leads to the formation of nitrogen-containing derivatives of 2-acetylthiophene. Sodium polysulfide assists the reductive fission of 3,3,3-trifluoro-1-(2-thenoyl)acetone.

Haloacetylated enol ethers, 19: Synthesis of 3-(2-thienyl)- and 3-(2-furyl)-5-trihalomethyl substituted azoles

Heterocyclization of 1,1,1-trifluoro[chloro]-4-methoxy-4-[2-tienyl]-3- buten-2-one and 1,1,1-trifluoro[chloro]-4-methoxy-4-[2-furyl]-3-buten-2-ones into isoxazoles and pyrazoles derivatives as a new type of trihalomethylated bicyclic heterocycles is reported. Georg Thieme Verlag Stuttgart.

Synthesis of 1,1,1-trihalo-4-methoxy-4-[2-heteroaryl]-3-buten-2-ones, the corresponding butan-1,3-dione and azole derivatives

The synthesis of 1,1,1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1,1,1-trihalo-4-methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1,3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2-acetylfuran are reported. This is a convenient method to obtain fluorinated and chlorinated 1,3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The fluorinated 1,3-dielectrophiles were used to synthesize five new 2-thienyl- and 2-furylazoles. The structure of all products were assigned by 1HH- and 13C NMR and mass spectrometry.

Formation and dehydration of a series of 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles

Reaction of five (3-oxo-4,4,4-trifluorobutanoyl)heterocycles with hydrazine hydrate under mild conditions gave the corresponding 3-heterocyclyl-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles. Thermal elimination of water from the 3-(thien-2-yl), 3-(pyridin-2-yl) and 3-(pyridin-4-yl) compounds readily gave the corresponding pyrazoles but acid catalysis was required to form 3-(benzothiazol-2-yl)-5-trifluoromethylpyrazole and 3-(1-methylbenzimidazol-2-yl)-5-trifluoromethylpyrazole. More forcing conditions were required for the analogous dehydration/aromatisations giving 3,5-bis(trifluoromethyl)-1-(4-nitrophenyl)pyrazole and 3,5-bis(trifluoromethyl)-1-pentafluorophenylpyrazole.