5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole

Base Information

• Chemical Name: 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole
• CAS No.: 128228-96-6
• Molecular Formula: C8H5F3N2S
• Molecular Weight: 218.202
• Hs Code.: 2933199090
• Mol file: 128228-96-6.mol

Synonyms:3-thiophen-2-yl-5-(trifluoromethyl)-1H-pyrazole

Chemical Property of 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole

Chemical Property:

• Melting Point: 120-122°C
• Boiling Point: 335.7°Cat760mmHg
• Flash Point: 156.8°C
• PSA: 56.92000
• Density: 1.461g/cm³
• LogP: 3.15700
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(Thien-2-yl)-3-(trifluoromethyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole

There total 5 articles about 5-(thiophen-2-yl)-3-(trifluoroMethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-Hydroxy-3-(thien-2-yl)-5-trifluoromethyl-4,5-dihydropyrazole → 3-(thien-2-yl)-5-trifluoromethyl-1H-pyrazole (128228-96-6)

Guidance literature:

With sulfuric acid; In ethanol; for 0.5h; Heating;

DOI:10.1016/S0022-1139(99)00011-1

Reference yield: 84.0%

(E)-1,1,1-Trifluoro-4-methoxy-4-thiophen-2-yl-but-3-en-2-one → 3-(thien-2-yl)-5-trifluoromethyl-1H-pyrazole (128228-96-6)

Guidance literature:

With hydrazine hydrate; In chloroform; at 25 - 30 ℃; for 2h;

DOI:10.1055/s-2005-872140

Reference yield:

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione (326-91-0) → 3-(thien-2-yl)-5-trifluoromethyl-1H-pyrazole (128228-96-6)

Guidance literature:

With hydrazine; In chloroform; at -10 ℃; for 1h;

DOI:10.1016/S0040-4039(02)02137-8

upstream raw materials:

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

Downstream raw materials:

C₂₂H₁₃F₃N₂S

Refernces

• 1、 Flores, Alex F. C.,Brondani, Sergio,Pizzuti, Lucas,Martins, Marcos A. P.,Zanatta, Nilo,Bonacorso, Helio G.,Flores, Darlene C.. "Haloacetylated enol ethers, 19: Synthesis of 3-(2-thienyl)- and 3-(2-furyl)-5-trihalomethyl substituted azoles". . p. 2744 - 2750. Retrieved 2007/10/03.
• 2、 Singh, Shiv P.,Kumar, Dalip,Jones, Brian G.,Threadgill, Michael D.. "Formation and dehydration of a series of 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles". . p. 199 - 203. Retrieved 2007/10/03.