The invention discloses a preparation method of 1-(beta-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene. The method has the advantages of short route, no requirement on low temperature, solid starting raw materials and intermediate, convenience in purification, good stereoselectivity and the like.
-
Paragraph 0017; 0031-0039
(2017/11/16)
PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2
The present invention is directed to a novel process for the preparation of compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof; comprising: reacting a compound of formula (V) wherein LG1 is a leaving group, with a mixture of a zinc salt and an organo-lithium reagent; in a first hydrocarbon solvent; at a temperature in the range of from about -78°C to about room temperature; to yield a mixture of the corresponding compound of formula (VI), wherein M1 is lithium, and the zinc salt; admixing to the mixture of the compound of formula (VI) and the zinc salt, a first ether solvent; to yield the corresponding compound of formula (VII), wherein M2 is a reactive zinc species.
-
Page/Page column 95-96
(2012/11/06)
PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2
The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
-
Page/Page column 31
(2011/04/25)
More Articles about upstream products of 1283129-18-9
Get Best Price for1283129-18-9(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate)