1283129-18-9

Upstream product

• 898566-17-1 (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) 
• 81058-27-7 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide 
• 492-62-6 alpha-D-glucopyranose 
• 3282-30-2 pivaloyl chloride 
• 958300-05-5 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosylbromide 
• 1283129-24-7 C₃₆H₂₈F₂S₂Zn 

Downstream Products

• 842133-18-0 canagliflozin 

Relevant academic research and scientific papers

1 - (β - D - pyran glucosyl) - 4 - methyl - 3 - [5 - (4 - fluorophenyl) - 2 - thienyl methyl] benzene synthesis process

The invention discloses a preparation method of 1-(beta-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene. The method has the advantages of short route, no requirement on low temperature, solid starting raw materials and intermediate, convenience in purification, good stereoselectivity and the like.

PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2

The present invention is directed to a novel process for the preparation of compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof; comprising: reacting a compound of formula (V) wherein LG1 is a leaving group, with a mixture of a zinc salt and an organo-lithium reagent; in a first hydrocarbon solvent; at a temperature in the range of from about -78°C to about room temperature; to yield a mixture of the corresponding compound of formula (VI), wherein M1 is lithium, and the zinc salt; admixing to the mixture of the compound of formula (VI) and the zinc salt, a first ether solvent; to yield the corresponding compound of formula (VII), wherein M2 is a reactive zinc species.

PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2

The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.