- Preparation method of 3-methoxy-4-fluorobenzaldehyde
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The invention discloses a preparation method of 3-methoxy-4-fluorobenzaldehyde. The method comprises the following steps: (1) reacting 3,4-difluorobromobenzene serving as a starting raw material withsodium methoxide to generate a compound III; and (2) reacting the compound III with magnesium to generate a Grignard reagent, and reacting under the condition of N,N-dimethylformamide to generate a compound I, wherein the obtained product is the 3-methoxy-4-fluorobenzaldehyde. The preparation method provided by the invention is higher in yield.
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Paragraph 0023-0024; 0027-0028; 0031-0032; 0035-0036
(2021/02/10)
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- Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands
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In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.
- Ingoglia, Bryan T.,Buchwald, Stephen L.
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supporting information
p. 2853 - 2856
(2017/06/07)
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- COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF
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The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.
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Paragraph 0164; 0165
(2015/05/05)
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- COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF
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The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.
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Paragraph 0220; 0221
(2015/06/24)
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- MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN
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The present invention relates to use of a compound of formula (I), (Ia), or (Ib), wherein A, B, Z, R1and R2 have the meanings given in the specification, as a medicament for the treatment of a number of pain conditions, particularly chronic or nociceptive
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Page/Page column 43
(2008/12/07)
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- MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION
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The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R1 is selected from H and (C1-C6)alkyl R2 is selected from H and (C
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- Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart
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Fluorine-18 (t12:109.8min)-labeled analogues of metaraminol, 4-[18F]FMR ((1R,2S)-2-amino-1-(4-[18F]fluoro-3-hydroxy phenyl)-1-propanol) and 6-[18F]FMR ((1R,2S)-2-amino-1-(2-[18F]fluoro-5-hydroxyphenyl)-1-propanol), were synthesized as new positron-emission-tomography (PET) tracers for mapping cardiac adrenergic nerve terminals. Copyright
- Langer, Oliver,Dollé, Frédéric,Valette, Héric,Halldin, Christer,Vaufrey, Fran?oise,Fuseau, Chantal,Coulon, Christine,Ottaviani, Michéle,N?gren, Kjell,Bottlaender, Michel,Maziére, Bernard,Crouzel, Christian
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p. 677 - 694
(2007/10/03)
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- Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives
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The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as
- Claudi, Francesco,Cardellini, Mario,Cingolani, Gian Mario,Piergentili, Alessandro,Pertuzzi, Guidubaldo,Balduini, Walter
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p. 2408 - 2412
(2007/10/02)
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