128495-46-5

Usage

Chemical Properties

White to yellow to tan powder or crystal or crystalline powder

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014

InChI:InChI=1/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3

Upstream product

• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 
• 74385-37-8 methyl 4-fluoro-3-methoxy-benzoate 
• 194018-68-3 vanillin triflate 
• 68-12-2 N,N-dimethyl-formamide 
• 103291-07-2 4-bromo-1-fluoro-2-methoxy-benzene 
• 452-84-6 3-amino-4-fluorotoluene 
• 63762-79-8 2-fluoro-5-methylphenol 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 

Downstream Products

• 103438-85-3 4-fluoro-3-hydroxybenzaldehyde 
• 1027590-86-8 [1-(4-Fluoro-3-methoxy-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine 
• 870837-24-4 4-(4-bromo-1H-imidazol-1-yl)-3-methoxybenzaldehyde 
• 866207-54-7 N-(1-(4-fluoro-3-methoxybenzyl)piperidin-4-yl)-6-chlorothieno[2,3-d]pyrimidin-4-amine 
• 866206-62-4 6-Chloro-N-(1-((pyrimidin-5-yl)methyl)piperidin-4-yl)thieno[2,3-d]pyrimidin-4-amine, Monomaleate 
• 633335-94-1 1-fluoro-2-methoxy-4-vinylbenzene 
• 864960-95-2 3-(4-fluoro-3-methoxyphenyl)-2-propenoic acid ethyl ester 
• 103438-91-1 3-benzyloxy-4-fluorobenzaldehyde 
• 347176-70-9 3-benzyloxy-4-N,N-dimethylaminobenzaldehyde 
• 630424-79-2 (E)-3-(4-fluoro-3-methoxyphenyl) acrylic acid 
• 943845-47-4 C₁₃H₁₈FNO₃ 
• 433920-87-7 3-methoxy-4-(1H-pyrazol-1-yl)benzaldehyde 

Relevant academic research and scientific papers

Preparation method of 3-methoxy-4-fluorobenzaldehyde

The invention discloses a preparation method of 3-methoxy-4-fluorobenzaldehyde. The method comprises the following steps: (1) reacting 3,4-difluorobromobenzene serving as a starting raw material withsodium methoxide to generate a compound III; and (2) reacting the compound III with magnesium to generate a Grignard reagent, and reacting under the condition of N,N-dimethylformamide to generate a compound I, wherein the obtained product is the 3-methoxy-4-fluorobenzaldehyde. The preparation method provided by the invention is higher in yield.

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.

MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN

The present invention relates to use of a compound of formula (I), (Ia), or (Ib), wherein A, B, Z, R1and R2 have the meanings given in the specification, as a medicament for the treatment of a number of pain conditions, particularly chronic or nociceptive

MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION

The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R1 is selected from H and (C1-C6)alkyl R2 is selected from H and (C

Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart

Fluorine-18 (t12:109.8min)-labeled analogues of metaraminol, 4-[18F]FMR ((1R,2S)-2-amino-1-(4-[18F]fluoro-3-hydroxy phenyl)-1-propanol) and 6-[18F]FMR ((1R,2S)-2-amino-1-(2-[18F]fluoro-5-hydroxyphenyl)-1-propanol), were synthesized as new positron-emission-tomography (PET) tracers for mapping cardiac adrenergic nerve terminals. Copyright

Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives

The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as