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3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1290536-55-8 Structure
  • Basic information

    1. Product Name: 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one
    2. Synonyms: 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one
    3. CAS NO:1290536-55-8
    4. Molecular Formula:
    5. Molecular Weight: 324.498
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1290536-55-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one(1290536-55-8)
    11. EPA Substance Registry System: 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one(1290536-55-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1290536-55-8(Hazardous Substances Data)

1290536-55-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1290536-55-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,0,5,3 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1290536-55:
(9*1)+(8*2)+(7*9)+(6*0)+(5*5)+(4*3)+(3*6)+(2*5)+(1*5)=158
158 % 10 = 8
So 1290536-55-8 is a valid CAS Registry Number.

1290536-55-8Relevant articles and documents

Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- And optical imaging

Boros, Eszter,Kanagasundaram, Thines,Kopka, Klaus,Kramer, Carsten S.

, p. 7294 - 7298 (2020)

Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imagingin vitro. Importantly,

Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near-infrared fluorescent probe

Zhang, Hongxing,Liu, Jing,Liu, Chenlu,Yu, Pengcheng,Sun, Minjia,Yan, Xiaohan,Guo, Jian-Ping,Guo, Wei

, p. 60 - 69 (2017)

Lysosomes have recently been regarded as the attractive pharmacological targets for selectively killing of cancer cells via lysosomal cell death (LCD) pathway that is closely associated with reactive oxygen species (ROS). However, the details on the ROS-induced LCD of cancer cells are still poorly understood, partially due to the absence of a lysosome-targetable, robust, and biocompatible imaging tool for ROS. In this work, we brought forward a Si-rhodamine-based fluorescent probe, named PSiR, which could selectively and sensitively image the pathologically more relavent highly reactive oxygen species (hROS: HClO, HO[rad], and ONOO?) in lysosomes of cancer cells. Compared with many of the existing hROS fluorescent probes, its superiorities are mainly embodied in the high stability against autoxidation and photoxidation, near-infrared exitation and emission, fast fluorescence off?on response, and specific lysosomal localization. Its practicality has been demonstrated by the real-time imaging of hROS generation in lysosomes of human non-small-cell lung cancer cells stimulated by anticancer drug β-lapachone. Moreover, the probe was sensitive enough for basal hROS in cancer cells, allowing its further imaging applications to discriminate not only cancer cells from normal cells, but also tumors from healthy tissues. Overall, our results strongly indicated that PSiR is a very promising imaging tool for the studies of ROS-related LCD of cancer cells, screening of new anticancer drugs, and early diagnosis of cancers.

Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells

Chu, Yeonjeong,Shin, Min Chul,Sung, June,Park, Jongmin,Kim, Eunha,Lee, Sanghee

, p. 1642 - 1648 (2019)

Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe

Silicon incorporation in polymethine dyes

Pengshung, Monica,Neal, Patrick,Atallah, Timothy L.,Kwon, Junho,Caram, Justin R.,Lopez, Steven A.,Sletten, Ellen M.

, p. 6110 - 6113 (2020)

Methods to red-shift fluorophores have garnered considerable interest due to the broad utility of low energy light. The incorporation of silicon into xanthene and coumarin scaffolds has resulted in an array of visible and near-infrared fluorophores. Here,

Improved Xanthone Synthesis, Stepwise Chemical Redox Cycling

Bachman, James L.,Escamilla, P. Rogelio,Boley, Alexander J.,Pavlich, Cyprian I.,Anslyn, Eric V.

, p. 206 - 209 (2019)

A base-catalyzed direct oxidation of rhodamine, carborhodamine, and siliconrhodamine pyronines to the corresponding xanthones is studied. This methodology utilizes addition of water to split pyronines into xanthone and reduced xanthene, the latter of whic

High-Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on β-Lapachone-Triggered ROS Amplification Specific in Cancer Cells

Guo, Wei,Liu, Jing,Liu, Mengxing,Zhang, Hongxing

, p. 12992 - 12998 (2021)

Discrimination of cancer cells/tissues from normal ones is of critical importance for early diagnosis and treatment of cancers. Herein, we present a new strategy for high-contrast fluorescence diagnosis of cancer cells/tissues based on β-Lapachone (β-Lap, an anticancer agent) triggered ROS (reactive oxygen species) amplification specific in cancer cells/tissues. With the strategy, a wide range of cancer cells/tissues, including surgical tissue specimens harvested from patients, were distinguished from normal ones by using a combination of β-Lap and a Si-rhodamine-based NIR fluorescent ROS probe PSiR3 developed in this work with average tumor-to-normal (T/N) ratios up to 15 in cell level and 24 in tissue level, far exceeding the clinically acceptable threshold of 2.0. What's more, the strategy allowed the fluorescence discrimination of tumor tissues from inflammatory ones based on whether a marked fluorescence enhancement could be induced when treated with PSiR3 and β-Lap/PSiR3 combination, respectively.

The unprecedented J-aggregate formation of rhodamine moieties induced by 9-phenylanthracenyl substitution

Kim, Sooyeon,Fujitsuka, Mamoru,Tohnai, Norimitsu,Tachikawa, Takashi,Hisaki, Ichiro,Miyata, Mikiji,Majima, Tetsuro

, p. 11580 - 11583 (2015)

We report a substitution of 9-phenylanthracenyl group into rhodamine derivatives that can induce the J-aggregate formation of rhodamine moieties in the aqueous solution upon the addition of a halide ion. From X-ray crystallographic analysis, the dramatic red-shift in the absorption band (i.e. app. 100 nm) originates from the cooperative slipped-stacking of rhodamine and anthracene molecules.

A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing

Huang, Yi-Lin,Walker, Alison S.,Miller, Evan W.

, p. 10767 - 10776 (2015)

This paper describes the design and synthesis of a photostable, far-red to near-infrared (NIR) platform for optical voltage sensing. We developed a new, sulfonated silicon rhodamine fluorophore and integrated it with a phenylenevinylene molecular wire to create a Berkeley Red Sensor of Transmembrane potential, or BeRST 1 ("burst"). BeRST 1 is the first member of a class of far-red to NIR voltage sensitive dyes that make use of a photoinduced electron transfer (PeT) trigger for optical interrogation of membrane voltage. We show that BeRST 1 displays bright, membrane-localized fluorescence in living cells, high photostability, and excellent voltage sensitivity in neurons. Depolarization of the plasma membrane results in rapid fluorescence increases (24% ΔF/F per 100 mV). BeRST 1 can be used in conjunction with fluorescent stains for organelles, Ca2+ indicators, and voltage-sensitive fluorescent proteins. In addition, the red-shifted spectral profile of BeRST 1, relative to commonly employed optogenetic actuators like ChannelRhodopsin2 (ChR2), which require blue light, enables optical electrophysiology in neurons. The high speed, sensitivity, photostability and long-wavelength fluorescence profiles of BeRST 1 make it a useful platform for the noninvasive, optical dissection of neuronal activity.

Zn ratiometric fluorescent probe and preparation and application thereof

-

, (2021/03/31)

The invention provides a Zn ratiometric fluorescent probe and preparation and application thereof. The preparation method of the Zn ratiometric fluorescent probe comprises the following steps: dissolving silicopyrone in CH3CN at 0 DEG C in a nitrogen environment, stirring for 10 minutes, dropwise adding trifluoromethanesulfonic anhydride, stirring to react for 10 minutes, adding N,N, di (2-pyridylmethyl) ethylenediamine, stirring the mixture overnight at room temperature, removing the solvent under reduced pressure, and carrying out column chromatography separation to obtain the fluorescent probe. Ratio detection is realized by utilizing a hydrolysis principle, and the reaction belongs to an irreversible reaction and can be used for quantitatively detecting zinc ions.

Near-infrared silicon-based rhodamine fluorescent dye, preparation method and application of near-infrared silicon-based rhodamine fluorescent dye in mitochondrial meninges in-situ no-clean imaging

-

Paragraph 0091; 0093-0097, (2021/03/24)

The invention provides a near-infrared silicon-based rhodamine fluorescent dye, a preparation method and application of the near-infrared silicon-based rhodamine fluorescent dye in mitochondrialmeninges in-situ wash-free imaging. The structural formula of

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