Enantioselective synthesis of tertiary thiols by intramolecular arylation of lithiated thiocarbamates
Lithiation of N-aryl S-α-alkylbenzyl thiocarbamates leads to rearrangement with migration of the N-aryl ring to the anionic centre α to S, a process which generally proceeds with ca. 98% retention of stereochemistry and returns chiral benzylic tertiary thiols in high enantiomeric ratios.
MacLellan, Paul,Clayden, Jonathan
p. 3395 - 3397
(2011/05/04)
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