- Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
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Hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), are known to activate the family of Tropomyosin receptor kinases (TrkA, TrkB, and TrkC). Moreover, in
- Bagal, Sharan K.,Andrews, Mark,Bechle, Bruce M.,Bian, Jianwei,Bilsland, James,Blakemore, David C.,Braganza, John F.,Bungay, Peter J.,Corbett, Matthew S.,Cronin, Ciaran N.,Cui, Jingrong Jean,Dias, Rebecca,Flanagan, Neil J.,Greasley, Samantha E.,Grimley, Rachel,James, Kim,Johnson, Eric,Kitching, Linda,Kraus, Michelle L.,McAlpine, Indrawan,Nagata, Asako,Ninkovic, Sacha,Omoto, Kiyoyuki,Scales, Stephanie,Skerratt, Sarah E.,Sun, Jianmin,Tran-Dubé, Michelle,Waldron, Gareth J.,Wang, Fen,Warmus, Joseph S.
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- TANK-BINDING KINASE INHIBITOR COMPOUNDS
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Compounds having the following formula (I) and methods of their use and preparation are disclosed:
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Paragraph 0160
(2016/05/02)
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- TANK-BINDING KINASE INHIBITOR COMPOUNDS
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Compounds having the following formula (I) and methods of their use and preparation are disclosed:
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Page/Page column 60
(2015/12/24)
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- COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS
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The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.
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Page/Page column 70
(2012/11/06)
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- AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON
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The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).
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Page/Page column 96
(2011/05/05)
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